From: Effects of mutations in the effector domain of influenza A virus NS1 protein
NS1 protein | mRNA export | NXF1 binding | M1 mRNA binding | Functional alteration | References |
---|---|---|---|---|---|
WT | + | + | + | N/A | [12] |
N81a,b | − | − | − | Effector domain deletion | [14] |
R38A/K41Ab | − | − | − | dsRNA-binding | [15] |
F103S/M106Ib | + | + | + | Gain of CPSF inhibition | [16] |
Y89A | − | + | − | PI3K-binding | [17] |
Y89F | − | + | − | PI3K-binding | [8] |
E96A/97A | − | + | + | Trim25-binding | [9] |
W187R | + | + | + | Homo-dimerisation | [11] |