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Table 1 Genetic and phenotypic summary of the NS1 polypeptides used in this study

From: Effects of mutations in the effector domain of influenza A virus NS1 protein

NS1 protein mRNA export NXF1 binding M1 mRNA binding Functional alteration References
WT + + + N/A [12]
N81a,b Effector domain deletion [14]
R38A/K41Ab dsRNA-binding [15]
F103S/M106Ib + + + Gain of CPSF inhibition [16]
Y89A + PI3K-binding [17]
Y89F + PI3K-binding [8]
E96A/97A + + Trim25-binding [9]
W187R + + + Homo-dimerisation [11]
  1. aStop codon added at position 82
  2. bSee [4] for experimental data