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Table 1 Genetic and phenotypic summary of the NS1 polypeptides used in this study

From: Effects of mutations in the effector domain of influenza A virus NS1 protein

NS1 protein

mRNA export

NXF1 binding

M1 mRNA binding

Functional alteration

References

WT

+

+

+

N/A

[12]

N81a,b

Effector domain deletion

[14]

R38A/K41Ab

dsRNA-binding

[15]

F103S/M106Ib

+

+

+

Gain of CPSF inhibition

[16]

Y89A

+

PI3K-binding

[17]

Y89F

+

PI3K-binding

[8]

E96A/97A

+

+

Trim25-binding

[9]

W187R

+

+

+

Homo-dimerisation

[11]

  1. aStop codon added at position 82
  2. bSee [4] for experimental data