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Table 1 Criteria used for determining sepsis related, possibly sepsis related and non-sepsis related cause of death

From: Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study

Sepsis related death: all three statements apply
 Within 14 days of sepsis episode
 Significant OR confirmed infectious changes on radiology OR microbiology within 3 days of index episode
 Treated with intravenous antibiotics at the time of index episode
Possibly sepsis related death: at least three out of the six statements apply
 Within 30 days of the sepsis episode while in-patient
 Significant infection related laboratory results within 3 days of the index episode (CRP/WCC)
 Administration of multiple broad-spectrum antibiotics (intravenous or oral)
 Clinical symptoms convincing of infective origin (SIRS 3 or more) within 3 days of the index episode
 Unclear/unavailable data on infection on radiology OR microbiology
 Cause of death is “Sepsis”, “Pneumonia” or other infectious origin on death certificate
Non-sepsis related death: Statements 1 AND 2 PLUS either 3 OR 4 apply
 No infective changes on laboratory AND radiology investigations AND negative microbiology
 Newly discovered OR progression of advanced malignancy (T4 and above) on radiology or pathology
 Death after 30 days of the index episode if points 1 AND 2 apply AND previous limitations on level of care in place at the time of index episode
 Death after hospital discharge following the index episode if points 1 AND 2 apply OR Cause of death is non-infectious on the death certificate
  1. CRP C-reactive protein, WCC white cell count