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Table 1 Antiplasmodium activity of aqueous, methanol and chloroform extract of V. adoensis leaves against P. berghei in Swiss albino mice

From: Antiplasmodial activity of Vernonia adoensis aqueous, methanol and chloroform leaf extracts against chloroquine sensitive strain of Plasmodium berghei in vivo in mice

Test extracts

Dose (mg/kg/day)

Antiplasmodial activity

% Parasitaemia ± SEM

% Suppression ± SEM

Aqueous

NC

25.79 ± 1.00a

0.00a

200

15.72 ± 0.77b

39.04 ± 2.99b

400

12.21 ± 0.81b

52.62 ± 3.16c

600

7.15 ± 0.94c

72.26 ± 3.67d

Methanol

NC

21.23 ± 0.49a

0.00a

200

10.58 ± 0.83b

50.17 ± 3.91b

400

5.79 ± 0.96c

72.71 ± 4.52c

600

3.53 ± 0.23c

83.36 ± 1.12c

Chloroform

NC

27.66 ± 0.89a

0.00a

200

19.06 ± 0.46b

31.09 ± 1.66b

400

16.41 ± 0.46c

40.65 ± 1.60c

600

12.62 ± 0.76d

54.34 ± 2.78d

PC

0.00e

100.00e

  1. Values are presented as Mean ± SEM
  2. PC, positive control; NC, negative control (0.2 ml of 3% Tween 80)
  3. a,b,c,d,eValues in the same column followed by the same letter do not differ significantly (P > 0.05)