Antiplasmodial activity of Vernonia adoensis aqueous, methanol and chloroform leaf extracts against chloroquine sensitive strain of Plasmodium berghei in vivo in mice

Table 2 Effect of V. adoensis of aqueous, methanol and chloroform leaf extracts on the body weights of P. berghei infected mice

Test extracts	Dose (mg/kg/day)	Body weight		% Change
Test extracts	Dose (mg/kg/day)	Before treatment (D₀)	After treatment (D₄)	% Change
Aqueous	NC	28.22 ± 0.42	24.66 ± 0.29*	− 12.62^a
	200	27.74 ± 0.21	25.66 ± 0.52*	− 7.49^b
	400	29.08 ± 0.28	28.88 ± 0.71	− 0.68^b
	600	29.62 ± 0.18	28.46 ± 0.49	− 3.92^b
	PC	29.66 ± 0.38	28.82 ± 0.16	− 2.83^b
Methanol	NC	28.92 ± 0.30	25.82 ± 0.09*	− 10.72^a
	200	30.60 ± 0.31	28.53 ± 0.83	− 6.76^b
	400	30.08 ± 0.34	29.2 ± 0.68	− 2.93^b
	600	28.5 ± 0.36	28.2 ± 0.40	− 1.05^b
	PC	27.27 ± 0.26	27.12 ± 0.24	− 0.55^b
Chloroform	NC	26.58 ± 0.47	22.72 ± 0.27*	− 14.52^a
	200	51.67 ± 0.25	51.02 ± 0.46	− 1.26^b
	400	52.3 ± 0.36	52.12 ± 0.33	− 0.34^b
	600	53.16 ± 0.63	53.13 ± 0.64	− 0.06^b
	PC	51.42 ± 0.35	52.08 ± 0.55	1.28^b

Values are presented as Mean ± SEM
NC, negative control (0.2 ml of respective vehicle); PC, positive control (0.2 ml of CQ)
* There was significant change between D₀ and D₄ (P < 0.05)
^a,bValues in the same column followed by the same letter do not differ significantly (P > 0.05)

ISSN: 1756-0500