Fig. 1

Genomic organization of HOXA10 locus used for methylation analysis. CpG island (blue region) identified by MethPrimer program (upper and lower panel). Vertical red bars indicate relative positions of CpG sites that are numbered from 1 to 22 for fragment F1 (gray box), from 1 to 21 for fragment F2 (gray box) and from 1 to 10 for fragment F3 (gray box). Exon sequences are indicated as white box and intronic sequences as thick black line