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Table 2 Cox-proportional hazard analysis of predictors of TB incidence in children on ART at Debre-Markos Referral Hospital, Northwest Ethiopia from March 2005 to April 2017

From: Incidence of tuberculosis in children on antiretroviral therapy: a retrospective cohort study

Variables Bivariable Multivariable
p value HR (95% CI) p value HR (95% CI)
Age
 0–5 year 0.860 1.1 (0.4, 3.1)   
 5–10 year 0.861 1.1 (0.4, 3.0)   
 10–15 year   1   
Sex
 Male   1   
 Female 0.428 1.4 (0.7, 2.6)   
Residence
 Urban   1   1
 Rural 0.051 2.3 (1.0, 5.3) 0.333 1.7 (0.6, 5.0)
Parent status
 Both parents alive   1   1
 Paternal/maternal orphan 0.008 2.7 (1.3, 5.7) 0.875 0.9 (0.4,2.3)
 Double orphan 0.010 3.8 (1.4, 10.3) 0.434 0.6 (0.2,2.1)
WHO clinical stage
 Stage 1 and 2   1   1
 Stage 3 and 4 < 0.001 11.6 (5.5, 24.3) 0.020 3.0 (1.2, 7.7)*
CD4 count
 Below threshold 0.001 3.4 (1.7, 7.0) 0.157 1.8 (0.8,4.2)
 Above threshold   1   1
Hemoglobin
 < 10 mg/dl 0.001 3.5 (1.7, 7.3) 0.345 1.6 (0.6,3.9)
 ≥ 10 mg/dl   1   1
Nutritional status
 Underweight 0.003 2.8 (1.4, 5.5) 0.757 1.1 (0.5,2.5)
 Normal   1   1
Ever taking CPT
 Yes   1   1
 No < 0.001 7.2 (3.1,16.8) 0.507 1.4 (0.5,3.9)
Ever taking IPT
 Yes   1   1
 No 0.025 3.0 (1.1,7.7) 0.870 1.1 (0.4,3.1)
Months on care before ART
 ≤ 3 month   1   1
 > 3 month < 0.001 12.6 (6.2,25.7) 0.006 4.0 (1.5,10.6)*
ART adherence
 Good   1   1
 Ever had fair and poor < 0.001 17.4 (8.4,35.9) 0.005 4.0 (1.5,10.8)*
Months on care after ART
 ≤ 6 month < 0.001 13.1 (5.2,33.1) 0.011 5.5 (1.5,20.6)*
 > 6 month   1   1
  1. HR hazard ratio, CI confidence interval *independently significant at α 0.05