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Fig. 2 | BMC Research Notes

Fig. 2

From: Detection of phosphorothioated (PS) oligonucleotides in horse plasma using a product ion (m/z 94.9362) derived from the PS moiety for doping control

Fig. 2

Non-target analyses of phosphorothioated oligonucleotides (PSOs) in deproteined plasma. a Total ion chromatogram (TIC), data dependent acquisition (DDA) Explorer (Time versus Precursor MS/Charge for DDA dependents), DDA Explorer filtered by m/z 94.936 with 10 ppm mass tolerance of deproteinated plasma with 4.5 µg/mL oligo dT. b TIC, DDA Explorer, and DDA Explorer filtered by m/z 94.936 with 10 ppm mass tolerance of 100 ng/mL oligo 1 in deproteinated plasma with 4.5 µg/mL oligo dT. Phosphorothioated (PS) oligomers were selectively detected in a heavy biological matrix containing a 45 times higher concentration of a non-PS oligomer without any sequence information

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