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Fig. 1 | BMC Research Notes

Fig. 1

From: Anti-thrombotic effect of a factor Xa inhibitor TAK-442 in a rabbit model of arteriovenous shunt thrombosis stimulated with tissue factor

Fig. 1

Antithrombotic effect of TAK-442 in a modified rabbit arteriovenous shunt thrombosis model. In a rabbit model of arteriovenous shunt thrombosis stimulated with a thrombogenic silk thread soaked with recombinant human tissue factor, the thrombus-coated thread was weighed 15 min after shunt placement at each dose. The drug was administered as a bolus (two-thirds of total dose) followed by constant intravenous infusion (one-third of total dose) for 30 min prior to shunt placement. Data are expressed as mean ± standard error of the mean; n = 4 animals per treatment group. *P ≤ 0.025 versus vehicle (one-tailed Williams’ test)

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