Fig. 1

Antithrombotic effect of TAK-442 in a modified rabbit arteriovenous shunt thrombosis model. In a rabbit model of arteriovenous shunt thrombosis stimulated with a thrombogenic silk thread soaked with recombinant human tissue factor, the thrombus-coated thread was weighed 15 min after shunt placement at each dose. The drug was administered as a bolus (two-thirds of total dose) followed by constant intravenous infusion (one-third of total dose) for 30 min prior to shunt placement. Data are expressed as mean ± standard error of the mean; n = 4 animals per treatment group. *P ≤ 0.025 versus vehicle (one-tailed Williams’ test)