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Fig. 2 | BMC Research Notes

Fig. 2

From: Tumour associated lymphocytes in the pleural effusions of patients with mesothelioma express high levels of inhibitory receptors

Fig. 2

PE T cells consist of unique TCR clonotypes compared with peripheral blood. a Clonality score of bulk CD4+ and CD8+ populations in effusion and blood. b Scatter plot of the most frequent TCR clonotype abundance in PE versus PB, CD8+ T cells. Red circles represent 45 individual TCR clonotypes that were present at significantly higher frequencies in the effusion than in the blood. Blue circles represent twenty clonotypes at higher frequencies in the blood than PE. c Scatter plot of the differential abundance of TCR clonotypes in PE versus PB, CD4+ T cells. Ten clones present at higher frequencies in the blood, and three clones higher in PE. Dotted curve line represents threshold for statistical comparison. d Clonality score of PD-1+ T cells. e Scatter plot of differential abundance of TCR clonotypes in CD8+PD-1+ T cell populations. Twenty-one clones at higher frequencies in blood, thirty-one clones higher in PE. f Differential abundance in CD4+PD-1+ populations. Nineteen clones at higher frequencies in blood, twenty-seven clones higher in PE

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