Fig. 3

Cytokine measurements in plasma of rats after inoculation of Y. pestis. Cytokines measurement using a Novex Rat Cytokine Magnetic 10-Plex Panel for simultaneous quantitative determination of GM-CSF, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12 (p40/p70) and TNF-α. Cytokine concentrations (in pg/mL) measured in plasma at day 5 post-inoculation with 150 cfu of Y. pestis are presented (F1 rats as in Fig. 2). Lineage Betafo and lineage Toamasina are presented separately (Plot: median/box 25–75%/min–max, *significant difference)