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Table 1 Analyses of socioeconomic and health characteristics predictors for different levels of recruitment for Insight 46, with no adjustments

From: Using a birth cohort to study brain health and preclinical dementia: recruitment and participation rates in Insight 46

Variable A. Specific life course data available
Max n = 2689
B. Willingness for London-clinic
Max n = 1322
C. Attended
Max n = 841
D. Scanned
Max n = 502
OR P 95% CI OR P 95% CI OR P 95% CI OR P 95% CI
Sex
 Female Reference   Reference   Reference   Reference  
 Male 1.19 0.03 1.02, 1.38 0.92 0.48 0.74, 1.15 0.77 0.07 0.59, 1.02 0.89 0.76 0.43, 1.85
Childhood SEP
 Manual Reference   Reference   Reference   Reference  
 Non-manual 1.58 < 0.01 1.35, 1.85 1.57 < 0.01 1.26, 1.96 1.18 0.24 0.90, 1.56 2.04 0.06 0.96, 4.33
Educational attainment to age 26
 None Reference   Reference   Reference   Reference  
 Up to GCE (age 16) 2.03 < 0.01 1.66, 2.48 1.55 < 0.01 1.15, 2.08 1.74 0.01 1.16, 2.61 0.85 0.80 0.25, 2.86
 A-level and above (age 16+) 3.09 < 0.01 2.55, 3.73 2.29 < 0.01 1.74, 3.02 1.76 < 0.01 1.22, 2.54 0.77 0.64 0.25, 2.33
Adult SEP
 Manual Reference   Reference   Reference   Reference  
 Non-manual 2.22 < 0.01 1.88, 2.63 1.88 < 0.01 1.45, 2.43 1.70 < 0.01 1.20, 2.42 1.08 0.87 0.40, 2.92
Childhood cognitive score
 Bottom 10% Reference   Reference   Reference   Reference  
 Middle 80% 2.84 < 0.01 2.08, 3.88 2.60 < 0.01 1.52, 4.45 1.45 0.35 0.66, 3.18 1.20 0.87 0.15, 9.56
 Top 10% 3.23 < 0.01 2.19, 4.75 3.10 < 0.01 1.67, 5.75 1.90 0.15 0.80, 4.49 1.97 0.57 0.19, 20.56
Word learning test memory score at 69 years
 Bottom 10% Reference   Reference   Reference   Reference  
 Middle 80% 1.64 < 0.01 1.24, 2.17 1.51 0.05 1.00, 2.27 1.60 0.10 0.92, 2.80 1.21 0.80 0.27, 5.41
 Top 10% 2.45 < 0.01 1.63, 3.69 1.78 0.04 1.04, 3.03 2.11 0.04 1.05, 4.23 1.49 0.67 0.23, 9.50
Mental health prevalence at age 69
 No Reference   Reference   Reference   Reference  
 Yes 0.71 0.01 0.56, 0.91 0.77 0.14 0.55, 1.09 0.42 <  0.01 0.27, 0.66 0.30 0.01 0.11, 0.78
Lifetime smoking by 69 years
 Never smoker Reference   Reference   Reference   Reference  
 Ex-smoker 0.94 0.47 0.79, 1.12 0.90 0.38 0.70, 1.14 1.00 1.00 0.74, 1.35 0.48 0.12 0.19, 1.20
 Current smoker 0.51 < 0.01 0.38, 0.68 0.54 0.01 0.34, 0.86 0.43 0.01 0.23, 0.82 0.34 0.15 0.05, 1.58
Alcohol use at age 69
 Never Reference   Reference   Reference   Reference  
 Less than once a week 1.17 0.27 0.89, 1.54 0.93 0.72 0.64, 1.37 1.32 0.27 0.81, 2.16 0.32 0.18 0.03, 1.95
 2–3× per week 1.38 0.03 1.03, 1.85 1.48 0.06 0.99, 2.21 2.16 < 0.01 1.30, 3.59 0.36 0.35 0.04, 2.96
 4+ times per week 1.37 0.03 1.03, 1.83 1.36 0.12 0.92, 2.01 1.51 0.10 0.93, 2.47 0.44 0.44 0.05, 3.58
Weight status at age 69
 Underweight or normal Reference   Reference   Reference   Reference  
 Overweight 0.70 < 0.01 0.57, 0.87 0.83 0.17 0.63, 1.08 1.59 0.01 1.14, 2.22 0.50 0.25 0.16, 1.61
 Obese 0.59 < 0.01 0.47, 0.74 0.83 0.23 0.62, 1.12 1.33 0.12 0.93, 1.92 0.22 0.01 0.07, 0.69
Type II diabetes by age 69
 No Reference   Reference   Reference   Reference  
 Yes 0.69 < 0.01 0.54, 0.88 0.95 0.79 0.65, 1.38 1.18 0.49 0.73, 1.91 0.76 0.62 0.25, 2.27
Hypertension by age 69
 No Reference   Reference   Reference   Reference  
 Yes 0.60 < 0.01 0.51, 0.71 0.83 0.11 0.66, 1.04 0.92 0.54 0.69, 1.21 1.05 0.89 0.50, 2.19
Overall disease burden by age 69
None Reference   Reference   Reference   Reference  
 1 0.87 0.27 0.69, 1.11 1.36 0.05 1.00, 1.84 0.82 0.29 0.56, 1.19 1.09 0.86 0.42, 2.85
 2 0.81 0.12 0.62, 1.06 1.00 1.00 0.71, 1.41 0.86 0.50 0.55, 1.33 0.98 0.97 0.33, 2.91
 3+ 0.67 < 0.01 0.51, 0.88 1.14 0.47 0.80, 1.63 0.59 0.02 0.38, 0.92 0.74 0.59 0.25, 2.21
Self-rated health at age 68
 Poor Reference   Reference   Reference   Reference  
 Fair 1.22 0.45 0.73, 2.02 1.43 0.38 0.64, 3.19 1.49 0.54 0.42, 5.22 0.35 0.19 0.07, 1.67
 Good 1.57 0.07 0.97, 2.54 1.64 0.20 0.77, 3.51 2.97 0.08 0.89, 9.92 0.61 0.46 0.16, 2.29
 Very good 2.49 < 0.01 1.54, 4.04 2.11 0.05 0.99, 4.47 4.39 0.02 1.33, 14.54 0.80 0.74 0.22, 2.88
 Excellent 2.34 < 0.01 1.37, 4.00 2.98 0.01 1.31, 6.79 4.18 0.03 1.20, 14.55 1.00  - 1.00, 1.00
APOE status
 No e4 Reference   Reference   Reference   Reference  
 e4 heterozygous 0.87 0.19 0.72, 1.07 0.99 0.96 0.75, 1.31 0.98 0.93 0.69, 1.41 1.16 0.76 0.45, 2.95
 e4 homozygous 1.26 0.37 0.76, 2.07 0.70 0.28 0.37, 1.33 0.91 0.83 0.36, 2.25 0.76 0.80 0.09, 6.21
Residential distance from London centre (miles)
 < 60 Reference   Reference   Reference   Reference  
 60–120 0.92 0.42 0.75, 1.13 0.68 0.02 0.50, 0.93 1.35 0.09 0.95, 1.93 NA   
 120–180 0.91 0.39 0.74, 1.13 0.39 < 0.01 0.29, 0.54 1.13 0.53 0.77, 1.67    
 > 180 0.86 0.17 0.69, 1.07 0.38 < 0.01 0.27, 0.52 1.07 0.75 0.71, 1.60    
  1. SEP: socioeconomic position; OR: odds ratio; A: Comparing those who did not meet the specific life course data availability criteria vs those who did; B: comparing those who previously indicated they were not willing to attend a London-based clinic or did not respond vs those who were; C: comparing those who did not attend vs successfully attended; D: comparing those who were not scanned vs those successfully scanned
  2. Italic values indicate p < 0.05