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Table 2 Socioeconomic and health characteristics predictors of levels of recruitment for Insight 46, adjusting for sex, childhood and adult SEP and education

From: Using a birth cohort to study brain health and preclinical dementia: recruitment and participation rates in Insight 46

Variable A. Specific life course data available B. Willingness for London-clinic C. Attended D. Scanned
OR P 95% CI OR P 95% CI OR P 95% CI OR P 95% CI
Childhood cognitive score
 Bottom 10% Reference   Reference   Reference   Reference  
 Middle 80% 1.55 0.01 1.10, 2.19 1.66 0.07 0.96, 2.90 1.06 0.89 0.45, 2.48 1.26 0.84 0.14, 11.54
 Top 10% 1.06 0.79 0.68, 1.65 1.78 0.09 0.92, 3.44 1.28 0.60 0.50, 3.30 2.07 0.57 0.17, 25.65
Word learning test memory score at 69 years
 Bottom 10% Reference   Reference   Reference   Reference  
 Middle 80% 1.25 0.16 0.92, 1.70 1.27 0.28 0.82, 1.94 1.40 0.26 0.79, 2.49 1.15 0.86 0.25, 5.29
 Top 10% 1.56 0.07 0.97, 2.50 1.25 0.45 0.71, 2.21 1.77 0.13 0.85, 3.68 1.32 0.78 0.19, 8.94
Mental health prevalence at age 69
 No Reference   Reference   Reference   Reference  
 Yes 0.78 0.07 0.59, 1.02 0.91 0.60 0.63, 1.30 0.46 < 0.01 0.29, 0.73 0.28 0.01 0.10, 0.75
Lifetime smoking to 69 years
 Never smoker Reference   Reference   Reference   Reference  
 Ex-smoker 0.98 0.86 0.81, 1.19 0.90 0.42 0.70, 1.16 0.99 0.97 0.73, 1.35 0.47 0.11 0.18, 1.18
 Current smoker 0.64 0.01 0.46, 0.88 0.70 0.14 0.43, 1.12 0.48 0.03 0.25, 0.94 0.33 0.21 0.06, 1.86
Alcohol use at age 69
 Never Reference   Reference   Reference   Reference  
 Less than once a week 1.09 0.58 0.80, 1.48 0.91 0.63 0.61, 1.35 1.28 0.34 0.77, 2.13 0.32 0.29 0.04, 2.62
 2–3× per week 1.21 0.25 0.87, 1.68 1.22 0.35 0.80, 1.85 1.91 0.02 1.13, 3.25 0.45 0.46 0.05, 3.73
 4+ times per week 1.17 0.35 0.84, 1.61 1.11 0.62 0.74, 1.67 1.29 0.33 0.77, 2.16 0.54 0.57 0.06, 4.63
Overweight at age 69
 No Reference   Reference   Reference   Reference  
 Overweight 0.74 0.01 0.58, 0.94 0.89 0.40 0.67, 1.17 1.61 0.01 1.14, 2.28 0.39 0.15 0.10, 1.43
 Obese 0.67 < 0.01 0.52, 0.86 0.95 0.72 0.70, 1.28 1.45 0.05 0.99, 2.12 0.17 0.01 0.05, 0.62
Type II diabetes at age 69
 No Reference   Reference   Reference   Reference  
 Yes 0.83 0.18 0.63, 1.09 1.04 0.85 0.70, 1.53 1.21 0.46 0.73, 2.01 0.68 0.50 0.22, 2.06
Hypertension by age 69
 No Reference   Reference   Reference   Reference  
 Yes 0.61 < 0.01 0.51, 0.73 0.86 0.21 0.69, 1.09 0.92 0.58 0.69, 1.23 0.98 0.94 0.46, 2.07
Overall disease burden at age 69
None Reference   Reference   Reference   Reference  
 1 0.81 0.13 0.62, 1.06 1.31 0.09 0.96, 1.78 0.79 0.24 0.54, 1.16 1.18 0.74 0.45, 3.12
 2 0.70 0.02 0.52, 0.94 1.01 0.94 0.71, 1.44 0.84 0.44 0.53, 1.31 1.15 0.81 0.36, 3.67
 3+ 0.72 0.03 0.53, 0.97 1.23 0.28 0.85, 1.77 0.63 0.04 0.40, 0.99 0.71 0.54 0.23, 2.15
Self-rated health at age 68
 Poor Reference   Reference   Reference   Reference  
 Fair 1.05 0.85 0.62, 1.80 1.35 0.47 0.59, 3.08 1.40 0.61 0.39, 5.05 0.37 0.22 0.08, 1.81
 Good 1.30 0.31 0.78, 2.17 1.36 0.44 0.62, 2.97 2.66 0.12 0.77, 9.15 0.61 0.47 0.16, 2.35
 Very good 1.93 0.01 1.16, 3.22 1.65 0.21 0.76, 3.58 3.75 0.04 1.10, 12.77 0.91 0.88 0.25, 3.32
 Excellent 1.97 0.02 1.11, 3.50 2.07 0.09 0.89, 4.82 3.42 0.06 0.95, 12.29 1.00  - 1.00, 1.00
APOE status
 No e4 Reference   Reference   Reference   Reference  
 e4 heterozygous 0.85 0.13 0.68, 1.05 0.99 0.97 0.75, 1.32 0.98 0.93 0.68, 1.42 1.08 0.88 0.41, 2.80
 e4 homozygous 1.27 0.39 0.73, 2.21 0.79 0.50 0.40, 1.56 0.97 0.95 0.38, 2.46 0.66 0.70 0.08, 5.46
Residential distance to London centre (miles)
 < 60 Reference   Reference   Reference   Reference  
 60–120 0.99 0.92 0.79, 1.24 0.65 0.01 0.48, 0.90 1.21 0.09 0.96, 2.16 NA   
 120–180 0.99 0.91 0.78, 1.24 0.40 < 0.01 0.29, 0.55 1.19 0.39 0.80, 1.78    
 > 180 0.87 0.24 0.68, 1.10 0.36 < 0.01 0.26, 0.50 1.11 0.62 0.73, 1.68    
  1. SEP: socioeconomic position; OR: odds ratio. A: Comparing those that didn’t meet the specific life course data availability criteria vs those who did; B: comparing those that previously indicated they were not willing to attend a London-based clinic or didn’t respond vs those who were; C: comparing those that didn’t attend vs successfully attended; D: comparing those who were not scanned vs those successfully scanned
  2. Italic values indicate p < 0.05
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BMC Research Notes

ISSN: 1756-0500

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