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Table 2 Summary of the methodology for the study across three phases

From: The physical sequelae of perinatally acquired HIV in adolescents: a research proposal

  Phase one Phase two Phase three
Study design Semi-structured interviews A cohort study with a comparison group of age-matched participants Consensus for a model of care using NGT
Source of participants CHANGES at RMMCH (for phase three medical professionals will be sourced from the site)
Sample size Eight participants per group; 2 groups (early and middle phase adolescence: ages 10–14 and 15–17 years, respectively) 308 (154 HIV+ and 154 HIV− [matched]) participants Five to nine participants per group; 2 groups (representatives of PHIVA and of clinical experts)
Inclusion criteria PHIVA in CHANGES, aged 10–17 years Adolescents aged 10–17 years (HIV+ and −) PHIVA in CHANGES, aged 10–17 years
Interdisciplinary team member in field of HIV and adolescence
Exclusion criteria Physical/cognitive impairments preventing their participation
Physical/cognitive impairment not due to HIV
Procedure and instrumentation Individual, semi-structured interviews HIV related fatigue scale
Six minute walk test
Brief peripheral neuropathy screen
Standing broad jump
PedsQL 4.0
Body mass index
Nominal group technique for consensus on a model of care [37]
Data analysis Identify substantive statements
Inductive approach
Manifest analysis
Separate coding done to identify themes, subthemes and categories
Descriptive statistics
Appropriate tests of association
Logistic regression analysis
Qualitative data: inductive analysis as per phase one
Quantitative data: descriptive statistics of averages and means