Table 1 Summary of DNA glycosylase activity rate constants for hOGG1 variants
From: Thermostability and excision activity of polymorphic forms of hOGG1
hOGG1 variant | A0 (nM) | k1 (min−1) | k2 (nM min−1) |
|---|---|---|---|
Wild-type | 14.2 ± 0.3 | 1.4 ± 0.1 | 0.09 ± 0.01 |
R46Q | 10.5 ± 0.6 | 2.0 ± 0.6 | 0.14 ± 0.03 |
A85S | 14.3 ± 0.3 | 1.6 ± 0.1 | 0.08 ± 0.01 |
R154H | 8.4 ± 0.6 | 0.23 ± 0.03 | 0.14 ± 0.01 |
S232T | 10.5 ± 0.5 | 0.8 ± 0.1 | 0.15 ± 0.02 |