Inflammatory markers response to citrulline supplementation in patients with non-alcoholic fatty liver disease: a randomized, double blind, placebo-controlled, clinical trial

Table 1 Inflammatory biomarkers of patients at baseline and after 3 month

Characteristics	Baseline Mean ± SD	After 3 month Mean ± SD	P*	Change Mean ± SD	P^†
hs-CRP (ng/ml)
Cit	5696 ± 2862	3901 ± 2760	< 0.01	− 1794 ± 2025	0.02
Placebo	6323 ± 4812	6143 ± 4851	0.713	− 180.6 ± 1866
TNF-α (pg/ml)
Cit	15.1 ± 4.74	14.6 ± 2.01	0.66	− 0.55 ± 0.07	0.57
Placebo	18.5 ± 2.04	17.4 ± 1.57	0.05	− 1.29 ± 2.37
NF-κb (ng/mg protein)
Cit	2.46 ± 0.72	2.11 ± 0.42	0.02	− 0.30 ± 0.63	< 0.001
Placebo	1.99 ± 1.34	2.64 ± 0.72	0.09	0.64 ± 1.29

TNF-α tumor necrosis factor α, hs-CRP C_reactive protein, NF-κB nuclear factor kappa B cells
* P values indicate comparison within groups
^†P values indicate comparison between the changes of each variable between two groups

ISSN: 1756-0500