On the length, weight and GC content of the human genome

Table 3 Genomic, mRNA and transcriptomic GC contents in the investigated human conditions and other species

Species	Genomic GC%	mRNA GC%	Transcriptomic GC%	∆GC%^{(mRNA−Genomic)}	∆GC%^{(Transcriptomic−mRNA)}
H. sapiens DS-AMKL	40.89	48.80	48.21	7.91	− 0.59
H. sapiens MK		48.80	49.27	7.91	0.47
H. sapiens Hippocampus		48.83	48.85	7.94	0.03
H. sapiens Brain		48.83	48.92	7.94	0.09
D. rerio Brain	36.63	45.70	45.40	9.08	− 0.30
C. elegans	35.44	42.21	43.22	6.77	1.00
S. cerevisiae	38.30	39.63	40.21	1.34	0.58
E. coli	50.79	51.99	52.13	1.20	0.15

Genomic GC%: percentage of G (guanine), C (cytosine) and S (G or C, present only in H. sapiens and D. rerio assemblies); for H. sapiens the mean GC content between male and female genomes was used; mRNA GC%: percentage of G and C in the analysed messenger RNA set having an expression value together with mRNA sequences available (see “Methods” section for details); transcriptomic GC%: percentage of G and C in the sum of each mRNA GC count multiplied by its mean expression value for each biological condition; ∆GC%^{(mRNA−Genomic)}: difference between mRNA and genomic GC%; ∆GC%^{(Transcriptomic−mRNA)}: difference between transcriptomic and mRNA GC%