Table 3 Association between miRNA-21, PTEN and α-SMA expressions and outcomes of BA patients after Kasai procedure

Age at Kasai operation of ≥ 90 days (n = 9)

− 3.6 ± 4.4

0.01 ± 0.9

12.7 ± 3.6

Age of Kasai operation of < 90 days (n = 7)

− 2.5 ± 3.2

0.2 ± 1.9

13.8 ± 2.5

ΔΔC_T (95% CI)

− 1.1 (− 4.4 to 2.2)

− 0.2 (− 1.7 to 1.3)

− 1.2 (− 3.9 to 1.6)

Fold change (2^−ΔΔC_T)

2.1

1.1

2.3

p-value

0.65

0.45

0.39

Cirrhosis (ΔC_T ± SD) (n = 4)

− 0.8 ± 2.2

0.4 ± 2.3

12.4 ± 1.4

Non-cirrhosis (ΔC_T ± SD) (n = 12)

− 5.3 ± 3.9

− 0.03 ± 0.9

13.9 ± 4.3

ΔΔC_T (95% CI)

4.5 (1.8–7.2)

0.4 (− 1.2 to 2.0)

− 1.5 (− 4.2 to 1.2)

Fold change (2^−ΔΔC_T)

25

1.3

2.8

p-value

0.004*

0.76

0.44

Died (ΔC_T ± SD) (n = 9)

− 2.1 ± 4.1

0.3 ± 1.6

13.4 ± 3.2

Survived (ΔC_T ± SD) (n = 7)

− 4.1 ± 3.4

− 0.2 ± 1.0

12.5 ± 3.2

ΔΔC_T (95% CI)

1.9 (− 1.3 to 5.2)

0.5 (− 1.0 to 2.0)

0.9 (− 1.9 to 3.6)

Fold change (2^−ΔΔC_T)

3.8

1.5

1.8

p-value

0.22

0.35

0.52