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Table 3 Association between miRNA-21, PTEN and α-SMA expressions and outcomes of BA patients after Kasai procedure

From: microRNA-21 expressions impact on liver fibrosis in biliary atresia patients

  miRNA-21 PTEN α-SMA
Age at Kasai operation of ≥ 90 days (n = 9) − 3.6 ± 4.4 0.01 ± 0.9 12.7 ± 3.6
Age of Kasai operation of < 90 days (n = 7) − 2.5 ± 3.2 0.2 ± 1.9 13.8 ± 2.5
ΔΔCT (95% CI) − 1.1 (− 4.4 to 2.2) − 0.2 (− 1.7 to 1.3) − 1.2 (− 3.9 to 1.6)
Fold change (2−ΔΔCT) 2.1 1.1 2.3
p-value 0.65 0.45 0.39
Cirrhosis (ΔCT ± SD) (n = 4) − 0.8 ± 2.2 0.4 ± 2.3 12.4 ± 1.4
Non-cirrhosis (ΔCT ± SD) (n = 12) − 5.3 ± 3.9 − 0.03 ± 0.9 13.9 ± 4.3
ΔΔCT (95% CI) 4.5 (1.8–7.2) 0.4 (− 1.2 to 2.0) − 1.5 (− 4.2 to 1.2)
Fold change (2−ΔΔCT) 25 1.3 2.8
p-value 0.004* 0.76 0.44
Died (ΔCT ± SD) (n = 9) − 2.1 ± 4.1 0.3 ± 1.6 13.4 ± 3.2
Survived (ΔCT ± SD) (n = 7) − 4.1 ± 3.4 − 0.2 ± 1.0 12.5 ± 3.2
ΔΔCT (95% CI) 1.9 (− 1.3 to 5.2) 0.5 (− 1.0 to 2.0) 0.9 (− 1.9 to 3.6)
Fold change (2−ΔΔCT) 3.8 1.5 1.8
p-value 0.22 0.35 0.52
  1. * Mann–Whitney U test is used to search for statistical differences between groups and p < 0.05 is considered statistically significant