Preliminary study on the expression of endothelial cell biology related genes in the liver of dengue virus infected mice treated with Carica papaya leaf juice

Table 2 Endothelial cell biology genes that were affected by the FCPLJ treatment

Gene symbol	Description	Fold regulation^a	p value^b
CCL2	Chemokine (C–C motif) ligand 2	2.20	0.025930
ITGB3	Integrin beta 3	− 1.61	0.006935
FN1	Fibronectin 1	− 1.66	0.020792
ICAM1	Intercellular adhesion molecule 1	− 1.74	0.027272

AG129 mice were intraperitoneally inoculated with 2 × 10⁶ PFU dengue virus, New Guinea C strain and orally treated with 1000 mg/kg BW FCPLJ
^aFold regulations of > 1.5 and > − 1.5 were considered upregulation and downregulation, respectively as compared to the gene expression level in the infected group
^bThe differences in gene expression level was considered significance at a p value of < 0.05

ISSN: 1756-0500