Hazards to avoid in future neonatal studies of nasal high-frequency oscillatory ventilation: lessons from an early terminated trial

Table 2 Selected secondary outcomes, median (range) or n (%)

	nHFOV (n = 4)	nCPAP (n = 2)
Blood gas analysis 2 h after extubation
pH	7.31 (7.20–7.36)	7.25^a
pCO₂ (mmHg)	60 (52–63)	73^a
pO₂ (mmHg)	32 (25–42)	35^a
Other secondary outcomes
Successful extubation for > 72 h	3 (75)	0 (0)
Treatment failure	2 (50)	2 (100)
Successful rescue treatment	1 (25)	0 (0)
Reintubation	1 (25)	2 (100)
Highly viscous secretions	2 (50)	0 (0)
Duration of mechanical ventilation (days)	22.5 (15–54)	47 (40–54)
Duration of supplemental oxygen (days)	70 (51–118)	81 (80–82)
Intraventricular haemorrhage 3°–4°	0 (0)	2 (100)
Death or moderate to severe bronchopulmonary dysplasia^b	1 (25)	1 (50)

^aOne patient in the nCPAP group had no blood gas analysis due to reintubation less than 2 h after extubation.
^bCombined outcome of death or moderate to severe bronchopulmonary dysplasia

ISSN: 1756-0500