Table 1 Stimuli, potentiator or inhibitors of iBK formation
Stimulus | Final concentration in plasma | Site of action | Source |
|---|---|---|---|
Recombinant active KLK-1 | 10 nM | Kininogen cleavage, mostly low molecular weight form | DiaMedica, Inc. |
Pacific Hemostasis Kontact-APTT | 2% v/v without the calcium supplement | Particulate material that triggers the contact system | ThermoFisher Scientific |
Recombinant tPA (alteplase, Cathflow) | 169 nM | Plasminogen activation | Roche |
Enalaprilat | 130 nM | ACE inhibition | Kemprotec Ltd. (Maltby, UK) |
Lanadelumab (DX-2930), humanized monoclonal antibody | 500 nM | Inhibitor of plasma kallikrein [3] | Shire Intl. GmbH |
M293-D02, monoclonal antibody | 1 μM | Anti-lanadelumab neutralizing antibody [15] | Shire Intl. GmbH |
DX-1000, recombinant Kunitz-type inhibitor | 1 μM | Inhibitor of plasmin [2] | Shire Intl. GmbH |