Fig. 1
Responses of human cell lines to antibiotic combination treatment. Cytotoxicity assays were performed evaluating human cell lines HEK293, CA46, and OVCAR8 in response to the recombinant immunotoxin HB21-LR in the presence and absence of various antibiotics. EC50 values of each treatment condition are plotted. Error bars indicate standard error of the mean. All values are the average of at least three separate experiments. The P value shown is from a two-tailed, paired T test and reflects a significant difference between EC50 values of an antibiotic-treated and untreated control. Cell lines HEK293 (a), OVCAR8 (b), and CA46 (c) were evaluated in combination with antibiotics chloramphenicol, tetracycline, fusidic acid, kanamycin, linezolid, and streptomycin. Cell lines Ramos (d) and Raji (d) were evaluated in combination with chloramphenicol