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Table 2 Univariable and multivariable semi-parametric proportional hazard model on predictors with time to initial second-line ART regimen change among adults in Amhara Region (February 2008-April 2016) (n = 897)

From: Second-line antiretroviral therapy regimen change among adults living with HIV in Amhara region: a multi-centered retrospective follow-up study

Variables Status Crude HR (95% CI) Adjusted HR (95% CI)
Event Censored
Gender
 Female 234 215 Ref Ref
 Male 208 240 0.78 (0.64 0.94) 0.88 (0.71 1.08)
Age
 15–24 38 54 Ref Ref
 25–34 222 218 1.12 (0.79 1.58) 1.16 (0.81 1.65)
 35–44 133 138 0.92 (0.64 1.32) 1.03 (0.71 1.50)
 ≥ 45 49 45 1.02 (0.67 1.56) 0.89 (0.57 1.38)
BMI
 < 18.5 253 248 1.04 (0.85 1.28) 1.06 (0.86 1.32)
 18.5–24.99 150 174 Ref Ref
 ≥ 25 39 33 1.05 (0.75 1.48) 0.98 (0.69 1.4)
Educational status
 No formal education 157 160 Ref Ref
 Formal education 285 295 0.82 (0.67 0.99) 0.77 (0.61 0.97)*
Occupation
 Unemployed 188 169 Ref Ref
 Employed 132 151 0.86 (0.69 1.08) 1.02 (0.79 1.33)
 Others 122 135 0.94 (0.75 1.19) 1.08 (0.85 1.38)
WHO clinical stage
 I 236 197 Ref Ref
 II 42 52 0.87 (0.63 1.20) 0.75 (0.53 1.06)
 III 132 168 0.52 (0.42 0.64) 0.57 (0.45 0.73)*
 IV 32 38 0.55 (0.38 0.81) 0.64 (0.43 0.96)*
CPT given
 No 37 76 Ref Ref
 Yes 405 379 2.40 (1.72 3.37) 2.05 (1.45 2.89)*
Reason for switch
 Clinical failure 185 117 Ref Ref
 Immunological failure 203 212 0.59 (0.48 0.72) 0.64 (0.52 0.79)*
 Virological failure 37 103 0.29 (0.20 0.41) 0.36 (0.25 0.53)*
 Drug toxicity 17 23 0.43 (0.26 0.71) 0.48 (0.28 0.81)*
Functional status
 Working 378 395 Ref Ref
 Ambulatory 61 48 1.30 (0.99 1.71) 1.26 (0.94 1.69)
 Bedridden 3 12 1.10 (0.35 3.45) 0.94 (0.29 2.96)
INH given
 No 330 364 Ref Ref
 Yes 112 91 1.06 (0.85 1.31) 1.24 (0.99 1.56)
TB treatment
 No 367 382 Ref Ref
 Yes 75 73 0.77 (0.60 0.99) 0.99 (0.74 1.35)
CD4 cell count
 ≥ 100 cells/mm3 186 154 Ref Ref
 < 100 cells/mm3 256 301 0.79 (0.65 0.96) 0.82 (0.67 1.01)
  1. Ref. reference category
  2. * 95% confidence interval for significant predictors