Skip to main content

Table 1 Association analysis of allele frequency and genotype distribution between POAG cases and controls

From: Polymorphisms rs693421 and rs2499601 at locus 1q43 and their haplotypes are not associated with primary open-angle glaucoma: a case–control study

SNP locus Gene type Controls (%) POAG (%) OR (95% CI) p valuea
Rs693421 GG 43 (25.10 45 (24.3) 1.00 Reference
GT 91 (53.2) 89 (48.1) 0.93 (0.56–1.56) 0.791
TT 37 (21.6) 51 (27.6) 1.32 (0.73–2.39) 0.362
Additive 0.417
Dominant 1.05 (0.65–1.69) 0.860
Recessive 1.38 (0.85–2.24) 0.190
G 177 (52.0) 179 (48.0) 1.00 Reference
T 165 (48.0) 191 (52.0) 1.15 (0.85–1.54) 0.368
HWE P 0.390 0.616
Rs2499601 TT 48 (28.1) 47 (25.4) 1.00 Reference
TC 80 (46.7) 80 (43.2) 1.02 (0.61–1.70) 0.920
CC 43 (25.1) 58 (31.4) 1.38 (0.78–2.42) 0.265
Additive 0.429
Dominant 1.18 (0.72–1.92) 0.512
Recessive 1.36 (0.85–2.16) 0.195
T 176 (51.0) 174 (47.0) 1.00 Reference
C 166 (49.0) 196 (53.0) 1.19 (0.89–1.60) 0.236
HWE P 0.406 0.072   
  1. OR (95% CI): Odds ratio (95% confidence interval), HWE P: Hardy–Weinberg equilibrium p value
  2. aPearson Chi2 test