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Table 2 Histological and immunohistological results obtained in Vastus lateralis muscle biopsies pre- and post-training program for DM1 patients according to evaluator #1 and #2

From: Training program-induced skeletal muscle adaptations in two men with myotonic dystrophy type 1

 

Evaluator #

Patient 1

Patient 2

Pre

Post

Pre

Post

CSA (type I), mm2 (SD)

1

0.0053 (0.00058)

0.0073 (0.0004)*

0.0061 (0.0008)

0.0052 (0.0016)

2

0.0060 (0.001)

0.0077 (0.0003)*

0.0067 (0.0017)

0.0055 (0.0011)

CSA (type II), mm2 (SD)

1

0.0084 (0.0011)

0.0096 (0.0005)

0.0067 (0.0005)

0.0058 (0.0002)*

2

0.0084 (0.0011)

0.0101 (0.0004)*

0.0067 (0.0005)

0.0059 (0.0004)*

Proportion (type I), % (SD)

1

57.3 (2.6)

28.2 (1.8)*

56.7 (5.8)

52.3 (3.0)

2

56.6 (2.8)

28.7 (1.7)*

57.0 (4.4)

49.0 (7.6)*

Proportion (type II), % (SD)

1

42.7 (2.6)

71.8 (1.8)*

43.3 (5.8)

47.7 (3.0)

2

43.4 (2.8)

71.3 (1.7)*

43.0 (4.4)

51.0 (7.6)*

CNF proportion % (SD)

1

4.77 (3.4)

5.28 (3.4)

7.14 (6.3)

8.26 (2.9)

2

2.18 (2.4)

2.08 (1.7)

6.3 (5.4)

4.45 (1.5)

Neutrophil density, cells/mm3 (SD)

1

218 (113)

353 (125)

445 (237)

356 (164)

2

445 (286)

519 (244)

633 (168)

429 (170)

Macrophage density, cells/mm3 (SD)

1

2852 (413)

2642 (371)

4347 (803)

5158 (972)

2

3855 (669)

4273 (979)

5846 (1555)

7830 (501)*

  1. *Significant difference between pre- and post-training (p < 0.01)