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Table 1 Comparison of previously reported and our replication results with RA risk in Pakistanis

From: Exploration of shared genetic susceptibility loci between type 1 diabetes and rheumatoid arthritis in the Pakistani population

Gene/SNP

Chr.

Alleles (minor/major)

Variant type

Previously reported results (Kiani et al. [23])

Our replication results

MAF

p-value

FDR

MAF cases

MAF controls

OR

p-value

FDR

GLIS3/rs7020673

9p24.2

C/G

Intron

0.414664

2.86E−04

3.59E−03

0.47691

0.486506

0.9

7.99E−02

2.93E−01

C6orf173/rs9388489

6q22.32

A/G

Intron

0.371429

3.11E−03

1.92E−02

0.370573

0.350714

1.1

1.00E−01

2.93E−01

SKAP2/rs7804356

7p15.2

C/T

Intron

0.195271

2.47E−04

3.59E−03

0.210042

0.218705

0.9

1.25E−01

2.93E−01

MEG3/rs941576

14q32.2

G/A

Intron

0.27612

9.51E−03

4.21E−02

0.323276

0.306525

1.1

2.38E−01

4.16E−01

GDSMB/rs2290400

17q12

C/T

Intron

0.434973

3.48E−04

3.59E−03

0.449324

0.482143

0.9

3.42E−01

4.78E−01

LOC399716/rs947474

10q15.1

G/A

Upstream

0.158732

4.53E−03

2.34E−02

0.199242

0.17617

1.1

4.96E−01

5.79E−01

BACH2/rs11755527

6q15

G/C

Intron

0.404286

9.16E−04

7.09E−03

0.435294

0.421186

1

6.66E−01

6.66E−01

  1. MAF minor allele frequency, FDR false discovery rate