| |
Unstandardized coefficients
|
Confidence interval
|
Sig.
|
|---|
|
B
|
SE
|
Lower
|
Upper
|
|---|
|
a)
|
|
MMP9
|
0.68
|
0.25
|
0.18
|
1.18
|
0.008
|
|
Age
|
0.04
|
0.02
|
− 0.00
|
0.07
|
0.053
|
|
Gender
|
− 0.00
|
0.35
|
− 0.70
|
0.698
|
1.000
|
|
Smoking
|
0.25
|
0.37
|
− 0.48
|
0.97
|
0.856
|
|
BMI
|
0.01
|
0.03
|
− 0.05
|
0.07
|
0.856
|
|
Pain (VAS) rest baseline
|
0.34
|
0.08
|
0.19
|
0.49
|
< 0.001
|
|
Pain location (LRP or LBP)
|
0.79
|
0.36
|
0.09
|
1.49
|
0.027
|
|
Emotional distress (HSCL-10) baseline
|
0.74
|
0.32
|
0.10
|
1.38
|
0.023
|
|
R2
| | | | |
0.26
|
|
Adjusted R2
| | | | |
0.23
|
|
b)
|
|
OPRM1
|
− 0.72
|
0.38
|
− 1.46
|
0.02
|
0.058
|
|
Age
|
0.03
|
0.02
|
− 0.01
|
0.07
|
0.089
|
|
Gender
|
− 0.19
|
0.35
|
− 0.89
|
0.51
|
0.586
|
|
Smoking
|
0.33
|
0.37
|
− 0.40
|
1.06
|
0.367
|
|
BMI
|
0.01
|
0.03
|
− 0.05
|
0.07
|
0.742
|
|
Pain (VAS) rest baseline
|
0.34
|
0.08
|
0.19
|
0.49
|
< 0.001
|
|
Pain location (LRP or LBP)
|
0.88
|
0.36
|
0.18
|
1.59
|
0.014
|
|
Emotional distress (HSCL-10) baseline
|
0.64
|
0.33
|
− 0.01
|
1.28
|
0.052
|
|
R2
| | | | |
0.25
|
|
Adjusted R2
| | | | |
0.21
|
- Multivariable linear regression with pain intensity (VAS) at rest at 5 years as dependent variable. a) MMP9 as predictor adjusted for demographic and clinical confounders and controlled for emotional distress. b) OPRM1 as predictor adjusted for demographic and clinical confounders and controlled for emotional distress
