Persistent lumbar radicular and low back pain; impact of genetic variability versus emotional distress

BMC Research Notes

Table 2 Multivariable linear regression with pain intensity at rest 5 years as dependent variable

	Unstandardized coefficients		Confidence interval		Sig.
	B	SE	Lower	Upper	Sig.
a)
MMP9	0.68	0.25	0.18	1.18	0.008
Age	0.04	0.02	− 0.00	0.07	0.053
Gender	− 0.00	0.35	− 0.70	0.698	1.000
Smoking	0.25	0.37	− 0.48	0.97	0.856
BMI	0.01	0.03	− 0.05	0.07	0.856
Pain (VAS) rest baseline	0.34	0.08	0.19	0.49	< 0.001
Pain location (LRP or LBP)	0.79	0.36	0.09	1.49	0.027
Emotional distress (HSCL-10) baseline	0.74	0.32	0.10	1.38	0.023
R²					0.26
Adjusted R²					0.23
b)
OPRM1	− 0.72	0.38	− 1.46	0.02	0.058
Age	0.03	0.02	− 0.01	0.07	0.089
Gender	− 0.19	0.35	− 0.89	0.51	0.586
Smoking	0.33	0.37	− 0.40	1.06	0.367
BMI	0.01	0.03	− 0.05	0.07	0.742
Pain (VAS) rest baseline	0.34	0.08	0.19	0.49	< 0.001
Pain location (LRP or LBP)	0.88	0.36	0.18	1.59	0.014
Emotional distress (HSCL-10) baseline	0.64	0.33	− 0.01	1.28	0.052
R²					0.25
Adjusted R²					0.21

Multivariable linear regression with pain intensity (VAS) at rest at 5 years as dependent variable. a) MMP9 as predictor adjusted for demographic and clinical confounders and controlled for emotional distress. b) OPRM1 as predictor adjusted for demographic and clinical confounders and controlled for emotional distress

ISSN: 1756-0500