Fig. 1

Representative cases of reciprocal interaction of MCT4 and GPC3 in HCC. Serial sections of two independent HCC cases (a–f) were stained with hematoxylin and eosin (a, d), anti-MCT4 antibody (b, e), and anti-GPC3 antibody (c, f). MCT4-positive HCC cells tended to be located distantly from vascular networks (asterisks), whereas GPC3-positive HCC cells tended to be present in the perivascular areas. Asterisks in a–f represent vascular networks. Scale bars, 100 µm