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Table 1 Clinicopathological characteristics of patients with HCC according to the expression of MCT4 and GPC3

From: Intratumoral reciprocal expression of monocarboxylate transporter 4 and glypican-3 in hepatocellular carcinomas

Parameters

Reciprocal

n = 29

Non-reciprocal

n = 14 [synergistic/irrelevant]

p value

Age

 < 60

12

7 [3/4]

0.5943

 ≥ 60

17

7 [2/5]

Gender

 Male

18

13 [5/8]

0.0667

 Female

11

1 [0/1]

Recurrence

 New

25

10 [3/7]

0.4038

 Recurrent

4

4 [2/2]

Tumor size

 < 5 cm

15

7 [2/5]

0.9156

 ≥ 5 cm

14

7 [3/4]

Tumor multiplicity

 Single

21

11 [4/7]

> 0.9999

 Multiple

8

3 [1/2]

HBV

 Positive

16

6 [3/3]

0.4490

 Negative

13

8 [2/6]

HCV

 Positive

6

5 [2/3]

0.2900

 Negative

23

9 [3/6]

No HBV or HCV

 Yes

8

3 [0/3]

> 0.9999

 No

21

11 [5/6]

Serum AFP

 High ≥ 14

25

10 [5/5]

0.4038

 Low < 14

4

4 [0/4]

Serum PIVKA-IIa

 High ≥ 40

20

9 [4/5]

0.6369

 Low < 40

8

5 [1/4]

Child–Pugh score

 A

26

11 [5/6]

0.3728

 B

3

3 [0/3]

Pre-operative therapy

 Yes

3

5 [2/3]

0.0452

 No

26

9 [3/6]

Cirrhosis

 Yes

17

3 [1/2]

0.0275

 No

12

11 [4/7]

Capsular invasion

 Yes

21

9 [2/7]

0.5866

 No

8

5 [3/2]

Vascular invasion

 Yes

21

9 [4/5]

0.5866

 No

8

5 [1/4]

Tumor differentiationb

 Well

3

1 [0/1]

0.4239

 Moderate

17

11 [4/7]

 Poor

9

2 [1/1]

TNM stageb

 I

1

2 [0/2]

> 0.9999

 II

7

1 [1/0]

 III

12

8 [1/7]

 IV

9

3 [3/0]

  1. Italic values were statistically significant
  2. HBV hepatitis B virus, HCV hepatitis C virus, AFP alpha-fetoprotein, PIVKA-II protein induced by vitamin K absence or antagonist II
  3. an = 28
  4. bFisher’s exact test was performed for well—(TNM stage I + II) vs. moderately/poorly differentiated tumors (TNM stage III + IV). Numbers in brackets are synergistic/irrelevant HCC cases