The utility of PAX8 and SATB2 immunohistochemical stains in distinguishing ovarian mucinous neoplasms from colonic and appendiceal mucinous neoplasm

Table 2 Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) with their corresponding 95% confidence intervals for each individual immunohistochemical marker for detection of ovarian tumors

Immuno- histological marker	n (%)		% (95 Confidence interval: (Lower − Upper))
Immuno- histological marker	Ovary	Colon and appendix	Sensitivity	Specificity	PPV	NPV
CK7
Positive	39 (32%)	9 (12.5%)	78 (66−89)	87.5 (80−95)	81.3 (70 −92)	85.1 (77−93)
Negative	11 (22%)	63 (87.5%)	78 (66−89)	87.5 (80−95)	81.3 (70 −92)	85.1 (77−93)
CK20
Positive	12 (24%)	63 (87.5%)	24 (12−38)	12.5 (5−20)	16 (8−24)	19.1 (8−30)
Negative	38 (76%)	9 (12.5%)	24 (12−38)	12.5 (5−20)	16 (8−24)	19.1 (8−30)
CDX2
Positive	7 (14%)	66 (91.7%)	14 (4−23)	8.3 (2−15)	9.6 (3−16)	12.2 (3−21)
Negative	43 (86%)	6 (8.3%)	14 (4−23)	8.3 (2−15)	9.6 (3−16)	12.2 (3−21)
PAX8
Positive	16 (32%)	0 (0%)	32 (19−45)	100 (100 −100)	100 (100−100)	67.9 (59−77)
Negative	34 (68%)	72 (100%)	32 (19−45)	100 (100 −100)	100 (100−100)	67.9 (59−77)
SATB2
Positive	1 (2%)	38 (52.8%)	2 (0−6)	47.2 (36−59)	2.6 (0−8)	41 (30−52)
Negative	49 (98%)	34 (47.2%)	2 (0−6)	47.2 (36−59)	2.6 (0−8)	41 (30−52)

The sensitivity, specificity, PPV, and NPV was calculated for the primary mucinous ovarian neoplasms. Immunostains were considered “positive” if > 5% of the tumor cells expressed the marker, and “negative” if < 5% of the tumor cells expressed the marker

ISSN: 1756-0500