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Table 2 Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) with their corresponding 95% confidence intervals for each individual immunohistochemical marker for detection of ovarian tumors

From: The utility of PAX8 and SATB2 immunohistochemical stains in distinguishing ovarian mucinous neoplasms from colonic and appendiceal mucinous neoplasm

Immuno-
histological
marker
n (%)% (95 Confidence interval: (Lower − Upper))
OvaryColon and appendixSensitivitySpecificityPPVNPV
CK7
 Positive39 (32%)9 (12.5%)78 (66−89)87.5 (80−95)81.3 (70 −92)85.1 (77−93)
 Negative11 (22%)63 (87.5%)
CK20 
 Positive12 (24%)63 (87.5%)24 (12−38)12.5 (5−20)16 (8−24)19.1 (8−30)
 Negative38 (76%)9 (12.5%)
CDX2
 Positive7 (14%)66 (91.7%)14 (4−23)8.3 (2−15)9.6 (3−16)12.2 (3−21)
 Negative43 (86%)6 (8.3%)
PAX8
 Positive16 (32%)0 (0%)32 (19−45)100 (100 −100)100 (100−100)67.9 (59−77)
 Negative34 (68%)72 (100%)
SATB2
 Positive1 (2%)38 (52.8%)2 (0−6)47.2 (36−59)2.6 (0−8)41 (30−52)
 Negative49 (98%)34 (47.2%)
  1. The sensitivity, specificity, PPV, and NPV was calculated for the primary mucinous ovarian neoplasms. Immunostains were considered “positive” if > 5% of the tumor cells expressed the marker, and “negative” if < 5% of the tumor cells expressed the marker