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Table 1 List of FAM13A interacting proteins detected by two-hybrid-screening

From: Two-hybrid screening of FAM13A protein partners in lung epithelial cells

ProteinGenePBSAssociation with lung diseaseRef.
Cilia- and flagella-associated protein 97CFAP97ANo 
Heat shock cognate 71 kDa proteinHSPA8AInvolved in CFTR biogenesis and trafficking[20]
Regulated by corticoid in cell lysate of sputum of COPD patients[21]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform*PPP2R5E*AGenetically associated with lung cancer[22]
PP2A activity was strongly enhanced in NSCLC[23]
TBC1 domain family member 5TBC1D5AInduced by smoking and ozone (murine COPD model)[24]
Filamin-BFLNBCNo 
14-3-3 protein beta/alphaYWHABCInteract with and regulate surfactant protein A2[25]
Involved in lung cancer[26]
Enhancer of mRNA-decapping protein 4EDC4CNo 
Tyrosine-protein phosphatase non-receptor type 12PTPN12DHigh expression of PTPN12 is associated with favorable survival duration in patients with NSCLC[27]
Histone-lysine N-methyltransferaseSETMARDNo 
tRNA cytosine [34]-C(5)-methyltransferaseNSUN2DNo 
Retinal dehydrogenase 1ALDH1A1DALDH1 is a lung tumor stem cell-associated marker[28]
ALDH1 expression favorable prognosis in lung adenocarcinoma[29]
Polyubiquitin-BUBBDReduced protein expression in COPD lung tissues[30]
Eukaryotic initiation factor 4A-IEIF4A1DNo 
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform**PPP2R5A**ENo 
14-3-3 protein epsilonYWHAEEUpregulated in lung squamous cell carcinoma[31]
14-3-3 protein zeta/deltaYWHAZEIdentified as a metastasis enhancer gene in lung cancer[32]
Upregulated in lung cancer[33]
Differentially expressed in malignant bronchial epithelial cell line compared to control cell line[34]
More frequent increased expression in patients with resectable lung adenocarcinoma with an improved prognosis [35]
26S proteasome non-ATPase regulatory subunit 11PSMD11FDifferentially expressed in malignant bronchial epithelial cell line compared to control cell line[34]
  1. PBS Predicted Biological Score [9]; NSCLC non-small cell lung cancer
  2. *Interaction previously shown using an adult mouse brain library and PPP2R5E (full-length Xenopus B56ε) or **mouse FAM13A as bait in two-hybrid screening