Table 1 List of FAM13A interacting proteins detected by two-hybrid-screening

Cilia- and flagella-associated protein 97

CFAP97

A

No

Heat shock cognate 71 kDa protein

HSPA8

A

Involved in CFTR biogenesis and trafficking

[20]

Regulated by corticoid in cell lysate of sputum of COPD patients

[21]

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform*

PPP2R5E*

A

Genetically associated with lung cancer

[22]

PP2A activity was strongly enhanced in NSCLC

[23]

TBC1 domain family member 5

TBC1D5

A

Induced by smoking and ozone (murine COPD model)

[24]

Filamin-B

FLNB

C

No

14-3-3 protein beta/alpha

YWHAB

C

Interact with and regulate surfactant protein A2

[25]

Involved in lung cancer

[26]

Enhancer of mRNA-decapping protein 4

EDC4

C

No

Tyrosine-protein phosphatase non-receptor type 12

PTPN12

D

High expression of PTPN12 is associated with favorable survival duration in patients with NSCLC

[27]

Histone-lysine N-methyltransferase

SETMAR

D

No

tRNA cytosine [34]-C(5)-methyltransferase

NSUN2

D

No

Retinal dehydrogenase 1

ALDH1A1

D

ALDH1 is a lung tumor stem cell-associated marker

[28]

ALDH1 expression favorable prognosis in lung adenocarcinoma

[29]

Polyubiquitin-B

UBB

D

Reduced protein expression in COPD lung tissues

[30]

Eukaryotic initiation factor 4A-I

EIF4A1

D

No

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform**

PPP2R5A**

E

No

14-3-3 protein epsilon

YWHAE

E

Upregulated in lung squamous cell carcinoma

[31]

14-3-3 protein zeta/delta

YWHAZ

E

Identified as a metastasis enhancer gene in lung cancer

[32]

Upregulated in lung cancer

[33]

Differentially expressed in malignant bronchial epithelial cell line compared to control cell line

[34]

More frequent increased expression in patients with resectable lung adenocarcinoma with an improved prognosis 

[35]

26S proteasome non-ATPase regulatory subunit 11

PSMD11

F

Differentially expressed in malignant bronchial epithelial cell line compared to control cell line

[34]