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Table 2 Biochemical profile of the study participants

From: Evaluation of serum iron overload, AST:ALT ratio and log10ferritin:AST ratio among schizophrenia patients in the Kumasi Metropolis, Ghana: a case–control study

Variables

Total (n = 200)

Control (N = 50)

T (n = 75)

p-value

TN (N = 75)

#p-value

Markers of iron overload

 Serum iron (µmol/l)

37.2 ± 1.1

31.3 ± 1.8

33.5 ± 1.4

0.3519

44.9 ± 1.8

< 0.0001

 Serum UIBC (µmol/l)

60.9 ± 1.6

69.6 ± 2.1

66.2 ± 2.5

0.2846

40.0 ± 2.5

< 0.0001

 Serum TIBC (µmol/l)

95.2 ± 2.4

100.9 ± 3.7

99.6 ± 3.4

0.5374

84.9 ± 3.1

< 0.0001

 Serum ferritin (ng/ml)

92.1 ± 5.1

81.6 ± 7.5

94.3 ± 8.2

0.2827

97.0 ± 10.9

0.2956

 log10 (ferritin)

1.8 ± 0.0

1.8 ± 0.1

1.9 ± 0.0

0.5674

1.9 ± 0.0

0.3975

 Serum transferrin (g/l)

3.8 ± 0.1

4.02 ± 0.1

3.9 ± 0.1

0.3761

3.4 ± 0.1

< 0.0001

 % transferrin saturation

39.2 ± 0.8

31.01 ± 0.9

33.6 ± 1.0

0.3145

52.9 ± 1.6

< 0.0001

Markers of liver function

 Serum AST (U/l)

24.7 ± 0.9

20.9 ± 1.2

23.9 ± 1.2

0.0773

28.0 ± 1.8

0.0035

 Serum ALT (U/l)

17.9 ± 0.6

17.8 ± 1.4

17.4 ± 0.8

0.8240

18.5 ± 1.1

0.6570

 GGT (U/l)

29.3 ± 1.8

21.32 ± 1.3

29.7 ± 1.9

0.0503

36.98 ± 2.4

0.0418

 AST:ALT ratio

1.5 ± 0.0

1.29 ± 0.0

1.50 ± 0.1

0.0282

1.61 ± 0.1

0.0004

 log10ferrtin:AST ratio

0.087 ± 0.0

0.096 ± 0.0

0.084 ± 0.0

0.0448

0.080 ± 0.0

0.0113

  1. Values are presented as mean ± standard deviation (SD) and frequency (proportion) where appropriate
  2. UIBC unsaturated iron binding capacity, TIBC total iron binding capacity, AST aspartate aminotransferase, ALT alanine aminotransferase, T treatment, GGT gamma-glutamyl transferase, TN treatment naïve
  3. p-value (comparison between control and treatment)
  4. #p-value (comparison between control and treatment naïve)