A trend in prevalence of antimicrobial use and appropriateness of antimicrobial therapy in an acute care hospital from 2018 to 2019: repeated prevalence surveys in Japan

Table 3 The appropriateness of antimicrobial therapy according to survey year

	August 2018 (n = 43)^a	August 2019 (n = 51)^a	p-value^b
Appropriate^c	26 (60.6)	21 (41.2)	0.06
Inappropriate	17 (39.4)	30 (58.8)	0.06
Reasons for inappropriateness^d
No infection	7 (16.3)	5 (9.8)	0.35
Inappropriate dose or timing	9 (20.9)	6 (11.8)	0.14
Inappropriate duration	0 (0.0)	2 (3.9)	0.50
Inappropriate choice	0 (0.0)	4 (7.8)	0.25
Inappropriate spectrum^e	2 (4.7)	19 (37.3)	0.002

^aData are shown as numbers (percentages)
^bComparison between the 2018 survey and the 2019 survey was performed using Fisher’s exact test
^cThe appropriateness of antimicrobial therapy was determined by members of the infection control team of each hospital based on the results of microbial tests at the time of the survey, antibiograms of each hospital, and the Infectious Diseases Society of America Practical Guidelines
^dOne antimicrobial drug could be given for more than one reason
^eAntimicrobial therapy was judged to be inappropriate if there were alternative antimicrobial drugs that were equally effective and had narrower spectrum activity

ISSN: 1756-0500