TY - JOUR AU - Smyth, L. J. AU - Kilner, J. AU - Maxwell, A. P. AU - McKnight, A. J. PY - 2019 DA - 2019/12/21 TI - Comparison of methylation patterns generated from genomic and cell-line derived DNA using the Illumina Infinium MethylationEPIC BeadChip array JO - BMC Research Notes SP - 821 VL - 12 IS - 1 AB - Genomic DNA (gDNA) is the optimal source of DNA for methylation analysis. This study compared methylation patterns in gDNA derived from blood with cell-line derived DNA (clDNA) from the same individuals. The clDNA had been generated via an Epstein-Barr virus transformation of the participant’s lymphocytes. This analysis sought to determine whether clDNA has the potential to be utilised in lieu of finite/unavailable gDNA in methylation analyses using Illumina Infinium MethylationEPIC BeadChip arrays that assess 862,927 CpG sites. SN - 1756-0500 UR - https://doi.org/10.1186/s13104-019-4853-4 DO - 10.1186/s13104-019-4853-4 ID - Smyth2019 ER -