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Table 2 Biological processes and genes of differentially hypermethylation in FT-LBWs

From: Full-term low birth weight infants have differentially hypermethylated DNA related to immune system and organ growth: a comparison with full-term normal birth weight infants

GO termBiological processaGenesbFold enrichmentP
GO:0001550eOvarian cumulus expansionEREG, BMPR1B54.3430.036
GO:0044356cClearance of foreign intracellular DNA by conversion of DNA cytidine to uridineAPOBEC3A_B, APOBEC3A54.3430.036
GO:0006163dPurine nucleotide metabolic processGMPR2, NME/NM23, GUK116.3030.014
GO:0030225cMacrophage differentiationCASP8, CASP10, BMP49.0570.042
GO:0008637cApoptotic mitochondrial changesBH3, IFIT2, AIFM28.5800.047
GO:0040018ePositive regulation of multicellular organism growthGHR, GHRL, GPR21, GPAM6.2110.026
GO:0045071cNegative regulation of viral genome replicationIFI16, ADAR, APOBEC3A_B, APOBEC3A5.4340.037
GO:0006289dNucleotide-excision repairHUS1, ERCC1, RPA2, NEIL15.3020.039
GO:0050728cNegative regulation of inflammatory responseNLRP12, SHARPIN, GHRL, PBK, AOAH, SMPDL3B4.1270.015
GO:0001649eOsteoblast differentiationCREB3L1, FBL, SPP1, BMP4, ITGA11, ADAR3.1350.043
GO:0006468eProtein phosphorylationSTRADB, BMPR1B, STRADA, PBK, BRSK1, FER, CDK8, HUS1, LATS1, COQ8B, CCNT1, CAMKK1, MATK, TGFBR1, LTK1.7880.042
  1. FT-LBW: full-term low birth weight; GO: gene ontology
  2. aBiological process that were found to correspond to hypermethylated DNA in FT-LBW infants. P < 0.05 was considered significant
  3. bGenes found to be differentially methylated in the promoter region
  4. c“Immune system” category
  5. d“DNA metabolism and repair” category
  6. e“Organism growth and organization” category