Fig. 2

Highly-selective μ-opioid receptor antagonism had no effect on L-DOPA-induced AIMs. CTAP (10 mg/kg, i.p.) had no effect on either LAO or locomotor AIMs. a The mean total LAO AIMs scores over 180 min were plotted and there was no difference between vehicle (gray bar) and CTAP (black bar) condition (mean AIMs count ± SEM; n = 6; paired two-tailed t-test). b The mean total locomotor AIMs scores over 180 min were plotted and there was no difference between vehicle (gray bar) and CTAP (black bar) condition. Similarly, gCTAP5 (5 mg/kg, i.p.) had no effect on either LAO or locomotor AIMs. c The mean total LAO AIMs scores over 180 min were plotted and there was no difference between vehicle (gray bar) and gCTAP5 (black bar) condition. d The mean total locomotor AIMs scores over 180 min were plotted and there was no difference between vehicle (gray bar) and gCTAP5 (black bar) condition. In all graphs the mean AIMs counts ± SEM were plotted; n = 6; paired two-tailed t-test. e Time course of the LAO-AIMs (mean ± SEM) data after CTAP administration presented in (a). f Time course of the LAO-AIMs (mean ± SEM) data after gCTAP5 administration presented in (c)