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Fig. 2 | BMC Research Notes

Fig. 2

From: Post-developmental extracellular proteoglycan maintenance in attractin-deficient mice

Fig. 2

a Normal (Atrn+/mg−3J) kidney (H&E); bAtrnmg−3J/mg−3J kidney (H&E). Note in the normal condition the dense staining basement membrane surrounding each tubule which also forms a tight junction between the tubules. This staining is absent in the Atrn-mutant specimen. c, d Higher resolution images of images within insets (dotted lines) in a, b. Note that in both specimens there are interstitial cells between the tubules (arrows) but only in the normal section are these cells embedded in basement membrane. For all images, results are representative of more than 5 sections from 10 paired sibling comparisons. e Normal kidney; fAtrnmg−3J/mg−3J kidney (PAS stain). The intralumenal brush border of Atrnmg−3J/mg−3J kidney tubules is depleted of extracellular matrix on comparison with control kidney (white arrows), and the intertubular space is similarly depleted (yellow arrows). For all images, results are representative of more than 5 sections from 10 paired sibling comparisons

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