Fig. 3
From: Post-developmental extracellular proteoglycan maintenance in attractin-deficient mice
a Normal liver and bAtrnmg−3J/mg−3J liver (H&E stain). The sinusoids (white space between rows of hepatocytes) are readily apparent in the mutant mice. Glycogen does not stain with H&E leading to light areas within the control cells, an effect not seen in the mutant indicating depletion of glycogen. c, d Higher resolution images of images within insets (dotted lines) in a, b. White arrow identifies sinusoid, yellow arrows indicate intercellular space. e Normal liver; fAtrnmg−3J/mg−3J liver (PAS stain). Comparison of sinusoids (yellow arrows) clearly indicates presence of proteoglycan contributing to the perisinusoidal space of Disse in the control liver while such signal is absent in the attractin-deficient liver. Note also (at the yellow arrows) evidence for sinusoidal swelling in the Atrnmg−3J/mg−3J liver accompanied by a more general lack of inter-hepatocyte ECM on comparison with control