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Table 2 Comparison based on the biochemical diagnosis

From: Scintigraphy evaluation of hyperthyroidism and its correlation with clinical and biochemical profiles

Variables Hyperthyroidism Subclinical hyperthyroidism P value
Number 90 88 n/a
Mean age (years) 41.0 + 13.5 45.1 + 15.6 0.060
Female (%) 73.3 75 0.467
Presenting symptoms
 Dysphagia and/or hoarseness (%) 2.2 5.7 0.213
 Neck swelling (%) 7.8 4.6 0.281
 Neck tenderness (%) 4.4 0.0 0.063
 Weight loss (%) 13.3 3.4 0.016
 Tremor (%) 11.1 3.4 0.044
 Palpitation (%) 14.4 2.3 0.003
 Fatigue (%) 8.9 2.3 0.054
 Anxiety (%) 3.3 3.4 0.648
 Insomnia (%) 2.2 0.0 0.254
 Headache (%) 3.3 2.3 0.511
 Nausea and/or vomiting (%) 1.1 1.1 0.746
 Eye manifestations (%) 14.4 12.5 0.437
 Heat intolerance (%) 2.2 2.3 0.681
Comorbidities
 Upper respiratory tract infection (%) 13.3 13.6 0.563
 Hypertension (%) 12.2 19.3 0.137
 Hyperlipidemia (%) 11.1 9.1 0.422
 Type II Diabetes (%) 14.4 26.1 0.039
 Type I diabetes (%) 2.2 1.1 0.508
 Anemia (%) 5.6 12.5 0.087
 Dermatitis (%) 15.6 14.8 0.525
 Ischemic heart disease (%) 0.0 2.3 0.243
 Stroke (%) 0.0 2.3 0.243
 Deep vein thrombosis and/or pulmonary embolism (%) 2.2 1.1 0.508
Medications
 Carbimazole usage prior to the thyroid scan (%) 20.5 30.7 0.071
 Carbimazole usage after the thyroid scan (%) 14.4 10.2 0.266
 Carbimazole usage during the thyroid scan (%) 35.6 17.1 0.004
 Propranolol (%) 41.1 22.7 0.007
 Amiodarone (%) 0.0 1.1 0.494
 Artificial eye tears (%) 6.7 4.6 0.388
Laboratory data
 TSH (milli-international units per liter) 0.019 + 0.04 0.083 + 0.10 < 0.001
 Free T4 (pmol/L) 28.7 + 9.9 14.5 + 2.4 < 0.001
 Free T3 (pmol/L) 15.0 + 10.7 5.2 + 1.2 < 0.001
 Antithyroid peroxidase antibody (IU/mL) 137.2 + 228.9 736.2 + 1495.5 0.309
 Antithyroglobulin antibody (IU/mL) 140.6 + 185.1 384.7 + 657.8 0.161
 Vitamin D (ng/mL) 23.4 + 10.4 22.4 + 9.0 0.289
 Erythrocyte sedimentation rate (ESR) (mm/hr) 34.5 + 24.3 34.4 + 24.7 0.995
 C-Reactive protein (CRP) (mg/L) 9.8 + 12.4 11.3 + 9.3 0.719
Thyroid ultrasound
 Enlarged thyroid gland (%) 25.0 31.1 0.605
 Heterogenous (%) 52.2 61.4 0.337
 Hypervascular (%) 38.9 31.8 0.392
 Bilateral lymph node enlargement (%) 22.2 33.0 0.404
 Unilateral lymph node enlargement (%) 2.2 1.1
 Multiple lymph node enlargement (%) 27.8 38.6 0.093
 Single lymph node enlargement (%) 10.0 15.9
Thyroid uptake and scan
 Heterogenous (%) 26.7 48.9 0.006
0.006
 Homogenous (%) 66.7 43.2
 Mean uptake (%) 17.6 + 9.5 13.2 + 3.8 0.373
 Graves’ disease (%) 40 13.6 0.002
 Thyroiditis (%) 8.9 27.3
 Normal (%) 2.2 5.7
 Autonomous nodule (%) 6.7 3.4
 Toxic multi-nodular goiter (%) 34.4 40.9
 Simple goiter (%) 4.4 4.5
 Nodular goiter with cold nodule (%) 0.0 2.2
 Cold nodule (%) 1.1 1.1
 Toxic multi-nodular goiter with a cold nodule (%) 1.1 1.1
 Marine-Lenhart syndrome (%) 2.2 0.0
 Normal scan while taking carbimazole (%) 17.8 11.4 0.159
  1. This Table shows a comparison based on the biochemical diagnosis between Hyperthyroidism and Subclinical hyperthyroidism patients. The means and standard deviations are used for quantitative variables like the age, thyroid uptake scan and laboratory parameter. Percentages are used to express all other qualitative data. An independent sample t-test is used to identify significant differences between variables, and p-values ≤0.05 are considered significant