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Table 3 Comparison based on thyroid uptake scans results

From: Scintigraphy evaluation of hyperthyroidism and its correlation with clinical and biochemical profiles

Variables Grave’s disease Toxic solitary/multinodular goiter P value
Number 53 86 n/a
Mean age (years) 35.8 + 11.1 43.7 + 14.6 0.001
Female (%) 73.6 77.9 0.351
Presenting symptoms
 Dysphagia and/or hoarseness (%) 3.8 3.5 0.633
 Neck swelling (%) 1.9 7.0 0.178
 Neck tenderness (%) 0.0 2.3 0.381
 Weight loss (%) 9.4 4.7 0.222
 Tremor (%) 13.2 5.8 0.117
 Palpitation (%) 7.5 5.8 0.471
 Fatigue (%) 7.5 2.3 0.149
 Anxiety (%) 5.7 0.0 0.053
 Insomnia (%) 0.0 2.3 0.381
 Headache (%) 3.8 1.2 0.324
 Nausea and/or vomiting (%) 1.9 0.0 0.381
 Eye manifestations (%) 13.2 15.1 0.481
 Heat intolerance (%) 1.9 2.3 0.676
Comorbidities
 Upper respiratory tract infection (%) 9.4 17.4 0.145
 Hypertension (%) 5.7 16.3 0.052
 Hyperlipidemia (%) 3.8 9.3 0.190
 Type II Diabetes (%) 7.5 24.4 0.009
 Type I diabetes (%) 3.8 1.2 0.324
 Anemia (%) 9.4 5.8 0.316
 Dermatitis (%) 9.4 15.1 0.242
 Ischemic heart disease (%) 0.0 1.2 0.619
 Stroke (%) 0.0 1.3 0.619
 Deep vein thrombosis and/or pulmonary embolism (%) 0.0 2.3 0.381
Medications
 Carbimazole usage prior to the thyroid scan (%) 28.3 30.2 0.482
 Carbimazole usage after the thyroid scan (%) 17.0 10.5 0.196
 Carbimazole usage during the thyroid scan (%) 47.2 20.9 0.001
 Normal thyroid uptake&scan while taking carbimazole (%) 13.2 15.1 0.481
 Propranolol (%) 49.1 27.9 0.010
 Artificial eye tears (%) 5.7 7.0 0.529
Laboratory data
 TSH (milli-international units per liter) 0.28 + 1.1 0.31 + 1.4 0.883
 Free T4 (pmol/L) 26.0 + 13.2 20.1 + 8.9 0.005
 Free T3 (pmol/L) 14.5 + 11.7 9.6 + 7.5 0.032
 Antithyroid peroxidase antibody (IU/mL) 216.4 + 287.0 251.4 + 500.2 0.831
 Antithyroglobulin antibody (IU/mL) 503.0 + 1009.0 355.6 + 1131.0 0.723
 Vitamin D (ng/mL) 21.7 + 11.1 21.6 + 9.2 0.967
 Erythrocyte sedimentation rate (ESR) (mm/hr) 29.3 + 20.4 33.0 + 22.9 0.697
 C-Reactive protein (CRP) (mg/L) 8.3 + 11.3 9.0 + 12.0 0.898
Thyroid ultrasound
 Enlarged thyroid gland (%) 32.1 25.6 0.591
 Heterogenous (%) 49.1 60.5 0.306
 Hypervascular (%) 39.6 40.7 0.976
 Bilateral lymph node enlargement (%) 18.9 30.2 0.297
 Unilateral lymph node enlargement (%) 1.9 0.0
 Multiple lymph node enlargement (%) 15.1 38.4 0.008
 Single lymph node enlargement (%) 13.2 15.1
Thyroid uptake and scan
 Heterogenous (%) 3.8 57.0 < 0.001
 Homogenous (%) 96.2 43.0
 Mean uptake (%) 19.7 + 16.2 16.0 + 6.4 0.598
Biochemical diagnosis
 Subclinical hyperthyroidism 22.6 45.3 0.039
 Hyperthyroidism 67.9 43.0
 Euthyroidism 3.8 9.3
 T3 thyro-toxicosis 1.9 1.2
 Hypothyroidism 1.9 0.0
 Subclinical hypothyroidism 1.9 1.2
  1. This table shows a comparison based on thyroid uptake scans results between Grave’s disease and Toxic solitary/multinodular goiter. The means and standard deviations are used for quantitative variables like the age, thyroid uptake scan and laboratory parameter. Percentages are used to express all other qualitative data. An independent sample t-test is used to identify significant differences between variables, and p-values ≤0.05 are considered significant