Table 1 The diagnostic values of EGFR plasma test between groups
Variable | Concordance | Sensitivity | Specificity | |||
|---|---|---|---|---|---|---|
Percentage (%) | P-value | Percentage (%) | P-value | Percentage (%) | P-value | |
Mutation type | ||||||
 EGFRE19del (n = 125) | 92.8 | 0.212 | 77.5 | 0.472 | 100.0 | 0.360 |
 EGFRL858R (n = 125) | 95.2 |  | 78.2 |  | 99.0 |  |
Age | ||||||
 ≥ 59 (n = 57) | 87.7 | 0.694 | 79.3 | 0.510 | 96.4 | 0.467 |
 < 59 (n = 68) | 85.3 |  | 72.2 |  | 100.0 |  |
Gender | ||||||
 Female (n = 37) | 83.8 | 0.290 | 80.0 | 0.424 | 100.0 | 0.714 |
 Male (n = 88) | 87.5 |  | 71.4 |  | 98.1 |  |
Ecog PS | ||||||
 0–1 (n = 101) | 84.2 | 0.191 | 70.6 | 0.159 | 98.0 | 0.833 |
 ≥ 2 (n = 24) | 95.8 |  | 92.9 |  | 100.0 |  |
Smoking status | ||||||
 No (n = 54) | 87.0 | 0.428 | 84.1 | 0.018 | 100.0 | 0.652 |
 Yes (n = 71) | 85.9 |  | 57.1 |  | 98.0 |  |
Clinical stage | ||||||
 IIIB (n = 6) | 83.3 | 0.592 | 66.7 | 0.578 | 100.0 | 0.950 |
 IV (n = 119) | 86.6 |  | 75.8 |  | 98.3 |  |
Lung metastasis | ||||||
 No (n = 86) | 84.9 | 0.334 | 73.3 | 0.404 | 97.6 | 0.683 |
 Yes (n = 39) | 89.7 |  | 80.0 |  | 100.0 |  |
Lymph-node | ||||||
 No (n = 42) | 85.7 | 0.874 | 75.0 | 0.956 | 100.0 | 0.700 |
 Yes (n = 83) | 86.8 |  | 75.6 |  | 97.6 |  |
Pleural effusion | ||||||
 No (n = 86) | 83.7 | 0.155 | 70.5 | 0.152 | 97.6 | 0.700 |
 Yes (n = 39) | 92.3 |  | 85.7 |  | 100.0 |  |
Distant metastasis | ||||||
 No (n = 25) | 88.0 | 0.545 | 80.0 | 0.461 | 100.0 | 0.833 |
 Yes (n = 100) | 86.0 |  | 74.0 |  | 98.0 |  |
 Tumor size | ||||||
 ≤ 5 cm (n = 43) | 84.2 | 0.233 | 70.0 | 0.164 | 97.0 | 0.700 |
 > 5 cm (n = 82) | 90.7 |  | 84.0 |  | 100.0 |  |
Treatment: chemo-radiotherapy and/or surgery | ||||||
 No (n = 69) | 91.3 | 0.076 | 85.7 | 0.009 | 100.0 | 0.362 |
 Yes (n = 56) | 80.4 |  | 56.5 |  | 97.0 |  |
Treatment/Smoking status | ||||||
 No/No (n = 34) | 91.2 | 0.418 | 90.3 | 0.004 | 100.0 | 0.483 |
 No/Yes or Yes/No (n = 55) | 87.3 |  | 70.8 |  | 100.0 |  |
 Yes/Yes (n = 36) | 80.6 |  | 40.0 |  | 96.2 |  |