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Table 2 Estimated marginal means (95% confidence interval) for stearoyl-CoA desaturase activity indices, sulfur amino acids and related metabolites

From: Postprandial effects of a meal low in sulfur amino acids and high in polyunsaturated fatty acids compared to a meal high in sulfur amino acids and saturated fatty acids on stearoyl CoA-desaturase indices and plasma sulfur amino acids: a pilot study

  Group Baseline 1 h 2 h 3 h 4 h p for interaction
Fatty acids (μmol/L) and SCD
 16:0 Cys/Methigh + SFA 1690 (1310, 2070) 1750 (1370, 2120) 1820 (1440, 2190) 1990 (1610, 2360) 1980 (1600, 2350) 0.437
Cys/Metlow + PUFA 1700 (1320, 2070) 1690 (1310, 2070) 1710 (1340, 2090) 1750 (1370, 2130) 1920 (1550, 2300)
 16:1n-7 Cys/Methigh + SFA 171 (105, 238) 184 (118, 251) 169 (103, 236) 187 (120, 253) 195 (129, 262) 0.429
Cys/Metlow + PUFA 141 (74.3, 208) 138 (71, 204) 131 (64, 197) 133 (66.1, 199) 149 (82.1, 215)
 18:0 Cys/Methigh + SFA 609 (533, 686) 644 (568, 721) 663 (587, 740) 720 (644, 797) 723 (647, 799) 0.101
Cys/Metlow + PUFA 621 (545, 697) 621 (545, 697) 621 (545, 697) 628 (552, 704) 693 (617, 769)
 18:1n-9 Cys/Methigh + SFA 1650 (1220, 2080) 1750 (1320, 2180) 1760 (1330, 2200) 1900 (1460, 2330) 1910 (1480, 2340) 0.439
Cys/Metlow + PUFA 1770 (1340, 2200) 1760 (1330, 2190) 1800 (1370, 2230) 1860 (1420, 2290) 2120 (1690, 2550)
 SCD-16 Cys/Methigh + SFA 0.10 (0.07, 0.12) 0.10 (0.08, 0.13) 0.09 (0.07, 0.12) 0.09 (0.07, 0.12) 0.10 (0.07, 0.12) 0.788
Cys/Metlow + PUFA 0.08 (0.06, 0.11) 0.08 (0.06, 0.11) 0.08 (0.05, 0.10) 0.0749 (0.05, 0.10) 0.08 (0.05, 0.10)
 SCD-18 Cys/Methigh + SFA 2.74 (2.09, 3.39) 2.73 (2.08, 3.38) 2.69 (2.04, 3.34) 2.63 (1.98, 3.28) 2.67 (2.02, 3.32) 0.077
Cys/Metlow + PUFA 2.86 (2.21, 3.51) 2.85 (2.2, 3.5) 2.9 (2.25, 3.55) 2.95 (2.3, 3.6) 3.03 (2.38, 3.68)
Sulfur amino acids, μmol/L
 Methionine Cys/Methigh + SFA 25.1 (20.8, 29.3) 38.7 (34.5, 43.1) 34.1 (29.8, 38.3) 26.8 (22.6, 31.1) 23.4 (19.2, 27.7) < 0.001
Cys/Metlow + PUFA 23.5 (19.3, 27.8) 18.2 (13.9, 22.5) 15.1 (10.8, 19.4) 12.7 (8.46, 17.3) 13.2 (8.98, 17.5)
 SAM Cys/Methigh + SFA 97.3 (86.6, 108) 109 (97.9, 119) 101 (90.5, 112) 95.7 (84.9, 106) 94.2 (83.4, 105) < 0.001
Cys/Metlow + PUFA 99.7 (88.9, 110) 88.6 (77.8, 99.3) 81.3 (70.5, 92.1) 78.1 (67.4, 88.9) 78.8 (68, 89.6)
 SAH Cys/Methigh + SFA 14 (11.8, 16.2) 15.4 (13.2, 17.6) 14.4 (12.2, 16.6) 13.7 (11.5, 15.9) 13.2 (11.2, 15.4) 0.040
Cys/Metlow + PUFA 13.8 (11.6, 15.9) 13.1 (10.9, 15.2) 12.1 (9.88, 14.2) 10.9 (8.68, 13) 10.6 (8.46, 12.8)
 SAM/SAH Cys/Methigh + SFA 7.1 (6.2, 8.01) 7.19 (6.28, 8.09) 7.22 (6.32, 8.13) 7.14 (6.23, 8.04) 7.29 (6.39, 8.21) 0.424
Cys/Metlow + PUFA 7.27 (6.37, 8.18) 6.8 (5.9, 7.71) 6.76 (5.86, 7.66) 7.21 (6.31, 8.12) 7.43 (6.53, 8.34)
Total homocysteine Cys/Methigh + SFA 8.61 (6.87, 10.4) 9.23 (7.49, 11.0) 8.27 (6.53, 10.2) 7.09 (5.35, 8.83) 6.71 (4.97, 8.45) < 0.001
Cys/Metlow + PUFA 7.98 (6.23, 9.72) 7.58 (5.84, 9.32) 7.74 (6.01, 9.48) 7.41 (5.67, 9.16) 7.39 (5.65, 9.13)
Cystathionine, nmol/L Cys/Methigh + SFA 156 (112, 199) 254 (211, 298) 281 (237, 324) 275 (231, 319) 246 (202, 289) < 0.001
Cys/Metlow + PUFA 127 (83.4, 171) 113 (69.3, 157) 98.3 (54.6, 142) 94.8 (51.2, 138) 98.3 (54.7, 142)
Total cysteine Cys/Methigh + SFA 228 (204, 252) 231 (207, 255) 231 (207, 256) 224 (199, 248) 225 (201, 250) 0.387
Cys/Metlow + PUFA 235 (210, 259) 224 (199, 248) 218 (194, 243) 218 (194, 242) 216 (192, 241)
Total GSH Cys/Methigh + SFA 5.97 (4.29, 7.65) 5.7 (4.02, 7.39) 4.44 (2.75, 6.12) 5.72 (4.04, 7.41) 5.3 (3.62, 6.98) 0.169
Cys/Metlow + PUFA 4.03 (2.35, 5.71) 5.37 (3.69, 7.05) 5.28 (3.59, 6.96) 5.35 (3.67, 7.03) 5.1 (3.42, 6.78)
Taurine Cys/Methigh + SFA 85.7 (65.3, 106) 86.8 (66.4, 107) 68.5 (48.1, 88.9) 77.1 (56.7, 97.5) 81 (60.6, 101) 0.082
Cys/Metlow + PUFA 54.8 (34.3, 75.2) 58.5 (38.1, 78.9) 65.1 (44.7, 85.5) 69.6 (49.1, 90) 76.1 (55.7, 96.5)
  1. Cys/Methigh + SFA, meal with high contents of cysteine, methionine and saturated fatty acids; Cys/Metlow + PUFA, meal with low contents of cysteine and methionine, and high contents of polyunsaturated fatty acids; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; GSSG, oxidized glutathione; GSH, glutathione; SCD, steraoyl-CoA desaturase