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Table 3 Genotype distribution of two BDNF SNPs of FMS and its clinical features

From: Polymorphisms of brain-derived neurotrophic factor genes are associated with anxiety and body mass index in fibromyalgia syndrome patients

Clinical feature scores based on genotype distribution of BDNF SNPs

 

rs2049046

rs7124442

AA (n = 26)

AT (n = 33)

TT (n = 13)

p

GG (n = 6)

GA (n = 28)

AA (n = 38)

p

Pain

6.0 ± 0.4

5.4 ± 0.3

5.9 ± 0.6

N.S

6.5 ± 0.6

5.7 ± 0.4

5.6 ± 0.3

N.S

Fatigue

5.8 ± 0.4

6.0 ± 0.4

6.2 ± 0.6

N.S

5.0 ± 1.0

6.0 ± 0.4

6.1 ± 0.3

N.S

No. tender points

14.5 ± 0.6

15.4 ± 0.5

14.6 ± 0.8

N.S

15.5 ± 0.9

15.2 ± 0.5

14.6 ± 0.5

N.S

BMI

27.2 ± 1.1

27.6 ± 0.9

29.1 ± 1.5

N.S

24.7 ± 1.4

29.4 ± 1.1

26.9 ± 0.8

N.S

Anxiety

10.0 ± 0.8

10.4 ± 0.6

7.4 ± 1.1

< 0.002§

12.2 ± 1.9

9.6 ± 0.7

9.4 ± 0.6

N.S

Depression

8.3 ± 0.8

8.5 ± 0.7

7.5 ± 1.1

N.S

9.2 ± 1.4

7.8 ± 0.8

8.4 ± 0.6

N.S

Genotype distribution of two BDNF SNPs in different subgroups of clinical phenotypes

rs2049046

 

rs7124442

BMI

AA

AT

TT

 

BMI

AA

GA

GG

18.0–24.9

11

12

3

 

18.0–24.9

19

5

3

24.9–29.9

9

11

6

 

24.9–29.9

10

13

3

> 30

6

10

4

 

> 30

9

10

0

 

N.S

  

p = 0.032#

HADS-A

AA

AT

TT

 

HADS-A

AA

GA

GG

< 8

7

3

6

 

< 8

9

6

1

8–10

8

14

5

 

8–10

14

11

2

> 10

11

16

2

 

> 10

16

10

3

 

p = 0.048#

  

N.S

HADS-D

AA

AT

TT

 

HADS-D

AA

GA

GG

< 8

12

14

8

 

< 8

20

12

2

8–10

5

9

1

 

8–10

5

9

1

> 10

10

9

4

 

> 10

14

5

4

 

N.S

  

N.S

  1. SNP single nucleotide polymorphisms, BMI body mass index, HADS-A HADS-anxiety, HADS-D HADS-depression, N.S not significant
  2. §ANOVA test
  3. #χ2 Fisher’s exact test