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Table 3 Genotype distribution of two BDNF SNPs of FMS and its clinical features

From: Polymorphisms of brain-derived neurotrophic factor genes are associated with anxiety and body mass index in fibromyalgia syndrome patients

Clinical feature scores based on genotype distribution of BDNF SNPs
  rs2049046 rs7124442
AA (n = 26) AT (n = 33) TT (n = 13) p GG (n = 6) GA (n = 28) AA (n = 38) p
Pain 6.0 ± 0.4 5.4 ± 0.3 5.9 ± 0.6 N.S 6.5 ± 0.6 5.7 ± 0.4 5.6 ± 0.3 N.S
Fatigue 5.8 ± 0.4 6.0 ± 0.4 6.2 ± 0.6 N.S 5.0 ± 1.0 6.0 ± 0.4 6.1 ± 0.3 N.S
No. tender points 14.5 ± 0.6 15.4 ± 0.5 14.6 ± 0.8 N.S 15.5 ± 0.9 15.2 ± 0.5 14.6 ± 0.5 N.S
BMI 27.2 ± 1.1 27.6 ± 0.9 29.1 ± 1.5 N.S 24.7 ± 1.4 29.4 ± 1.1 26.9 ± 0.8 N.S
Anxiety 10.0 ± 0.8 10.4 ± 0.6 7.4 ± 1.1 < 0.002§ 12.2 ± 1.9 9.6 ± 0.7 9.4 ± 0.6 N.S
Depression 8.3 ± 0.8 8.5 ± 0.7 7.5 ± 1.1 N.S 9.2 ± 1.4 7.8 ± 0.8 8.4 ± 0.6 N.S
Genotype distribution of two BDNF SNPs in different subgroups of clinical phenotypes
rs2049046   rs7124442
BMI AA AT TT   BMI AA GA GG
18.0–24.9 11 12 3   18.0–24.9 19 5 3
24.9–29.9 9 11 6   24.9–29.9 10 13 3
> 30 6 10 4   > 30 9 10 0
  N.S    p = 0.032#
HADS-A AA AT TT   HADS-A AA GA GG
< 8 7 3 6   < 8 9 6 1
8–10 8 14 5   8–10 14 11 2
> 10 11 16 2   > 10 16 10 3
  p = 0.048#    N.S
HADS-D AA AT TT   HADS-D AA GA GG
< 8 12 14 8   < 8 20 12 2
8–10 5 9 1   8–10 5 9 1
> 10 10 9 4   > 10 14 5 4
  N.S    N.S
  1. SNP single nucleotide polymorphisms, BMI body mass index, HADS-A HADS-anxiety, HADS-D HADS-depression, N.S not significant
  2. §ANOVA test
  3. #χ2 Fisher’s exact test