Fig. 2

Homology comparison of S protein between coronavirus from different hosts. We compared the SARS-CoV-2_Wuhan_Hu-1 (human), RaTG13 (bat), RmYN02 (bat), MP789 (pangolin) and Pangolin group CoVs (PcoV_GX_P5L, P5E, P1E, P4L and P2V). The residues conserved in all sequences are colored in dark blue, highly conserved residues in medium blue and somewhat conserved residues in light blue. Residues marked with a red box are involved in the contact of the S protein with the ACE2 receptor. Dashes indicate deletions. The polybasic cleavage site is unique in SARS-CoV-2. RmYN02 CoV presents an insertion but this is not a polybasic cleavage site