The receptor binding domain of SARS-CoV-2 spike protein is the result of an ancestral recombination between the bat-CoV RaTG13 and the pangolin-CoV MP789

Table 1 McDonald-Kreitman test for Spike gene and RBD of SARS-CoV-2 comparing RaTG13 and MP789 CoVs

S gene	Polymorphic substitutions between virus		MK NI	Fisher’s exact test p value
S gene	Nonsynonymous	Synonymous	MK NI	Fisher’s exact test p value
RaTG13 CoV	33	223	12.839	0.00000
MP789 CoV	505	75	0.371	0.04134
RBD
RaTG13 CoV	26	60	ND	0.310345
MP789 CoV	7	71	ND	0.101266

ISSN: 1756-0500