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Table 1 McDonald-Kreitman test for Spike gene and RBD of SARS-CoV-2 comparing RaTG13 and MP789 CoVs

From: The receptor binding domain of SARS-CoV-2 spike protein is the result of an ancestral recombination between the bat-CoV RaTG13 and the pangolin-CoV MP789

S gene Polymorphic substitutions between virus MK
Fisher’s exact test
p value
Nonsynonymous Synonymous
RaTG13 CoV 33 223 12.839 0.00000
MP789 CoV 505 75 0.371 0.04134
 RaTG13 CoV 26 60 ND 0.310345
 MP789 CoV 7 71 ND 0.101266
  1. NI Neutrality index (significance at 95%)
  2. ND undetermined