Fig. 1

Clinical course after 60 min MCAo/reperfusion. a Brain ischemia induced clinical deficits corresponding to an increase of the median Bederson score values with a peak on day 3. None of the sham operated mice had an increased Bederson score; sham + mice with additional sciatic nerve crush injury showed a paralysed lower hind limb (not shown). b Histologic analysis of the brains revealed a marked atrophy of the infarcted hemisphere compared to the contralateral hemisphere. Statistical analyses: a Kruskal–Wallis test with Dunn’s method, in (c) unpaired two-sided t-test. * p < 0.05