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Fig. 2 | BMC Research Notes

Fig. 2

From: Focal brain ischemia in mice does not cause electrophysiological signs of critical illness neuropathy

Fig. 2

Serial nerve conduction velocity testing in the sciatic nerve after MCAo/reperfusion. a Representative recordings of CMAPs in the sciatic nerve obtained from mice after MCAo/reperfusion (grey dotted line) or sham operation (black solid line) on day 10 (left panel), 22 (middle panel), and 44 (right panel). b CMAP amplitude of MCAo and sham operated mice were comparable at all observed time points. c MCV remained unchanged in MCAo and sham-operated mice at all time points. d Representative sciatic nerve CMAP of a sham + mouse: CMAPs are virtually not detectable on day 10 (solid grey line, scale on left y-axis), severely decreased in its amplitude and delayed indicating slowed motor nerve conduction velocity with signs of temporal dispersion on day 22 (dashed grey line, scale on left y-axis) and fully regenerated on day 44 (solid black line, scale on right y-axis) after crush injury. e Crush injury to the sciatic nerve in sham + animals induced a severe decrease of the sciatic CMAP amplitude, which recovered by day 44. f The sciatic motor nerve conduction velocity (MCV) was severely decreased and steadily recovered in sham + mice. Statistical analysis: (b) 2-way ANOVA with Sidak post hoc, in (c) Kruskal–Wallis test with Dunn’s method

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