The effect of royal jelly and tocotrienol-rich fraction along with calorie restriction on hypothalamic endoplasmic reticulum stress and adipose tissue inflammation in diet-induced obese rats

Table 1 Comparison of weight and inflammatory indices in interventional groups

Variables	RJ	TRF	RJ + TRF	CRD	HFD
Weight	371.53 ± 8.22	404.74 ± 10.62	369.81 ± 6.58	404.26 ± 8.65	493.28 ± 8.23
P-Value*	0.045	0.989	0.032	< 0.001**
Weight change	− 67.21 ± 4.84	− 44.40 ± 3.36	− 73.29 ± 4.52	− 40.70 ± 6.50	+ 37.04 ± 5.56
P-value*	0.003	0.955	< 0.001	< 0.001**
TNF-α (pg/ml)	60 ± 2.63	56.84 ± 3.24	58.75 ± 4.78	79.66 ± 6.40	100.01 ± 6.09
P-value*	0.001	0.002	0.003	0.034**
MCP1 (pg/ml)	77.29 ± 2.10	82.45 ± 3.9	72.19 ± 2.94	99.41 ± 4.96	131.12 ± 7.37
P-value*	< 0.001	0.009	< 0.001	0.002**

Data are shown as the mean ± SEM; RJ, royal jelly; TRF, tocotrienol rich fraction; CRD, calorie restriction diet; HFD, high fat diet; TNF-α, tumor necrosis factor-α; MCP1, monocyte chemotactic protein1. * P-Value is indicated RJ, TRF and RJ + TRF versus CRD group by one-way ANOVA; ** P-Value is indicated CRD versus HFD group by t-test

ISSN: 1756-0500