Table 1 Summary of the study design
Groups | n | Time of application | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 6 | Day 7 | Day 8 | |||||||||||
9:00 | 16:00 | 9:00 | 16:00 | 9:00 | 16:00 | 9:00 | 16:00 | 9:00 | 16:00 | 9:00 | 16:00 | 9:00 | 16:00 | 9:00 | 16:00 | 9:00 | 16:00 | ||
I | 6 | VAS | – | VAS | – | VAS | – | VAS | – | VAS | – | VAS | – | VAS | – | VAS | – | VAS | – |
II | 6 | VAS | – | VAS | – | VAS | – | VAS | – | VAS | – | VAS | – | VAS | – | VAS | – | VAS | – |
III | 5 | IMQ | IMQ | IMQ | IMQ | IMQ | IMQ | IMQ | IMQ | IMQ | IMQ | IMQ | IMQ | IMQ | IMQ | IMQ | IMQ | IMQ | IMQ |
IV | 5 | IMQ | – | IMQ | – | IMQ | – | IMQ | – | IMQ | – | IMQ | – | IMQ | – | IMQ | – | IMQ | – |