Code | Weight n = 20 | Active substance contentb n = 20 | Hardnessc n = 10 | Friabilityd n = 20 | Disintegratione (phosphate buffer) n = 6 | Dissolutionf (phosphate buffer) n = 8 | ||
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Mean (SD) mg | Rangea % from mean | Mean (SD) mg | Mean (SD) % of label | Mean (SD) kg | %Loss | Range Minute: second | Mean (range) release at 45 min% of label | |
R | 212.9 (3.6) | 97–103 | 51.0 (1.7) | 102.0 (3.4) | 15.4 (1.1) | 0.24 | 15:00–15:00 | 100 (99–103) |
G1 | 203.7 (3.0) | 97–102 | 55.7 (0.9) | 111.3 (1.7) | 20.1 (1.7) | 1.10 | 14:09–14:09 | 81(69–90) |
G2 | 208.9 (4.3) | 95–103 | 53.8 (2.0) | 107.6 (4.0) | 16.6 (1.2) | 0.00 | 17:23–19:19 | 106 ( 102–109) |
G3 | 192.5 (3.5) | 96–103 | 49.3 (2.0) | 98.6 (4.0) | 12.8 (0.4) | 0.00 | 13:29–13:29 | 101 (94–113) |
G4 | 283.6 (4.0) | 97–103 | 50.9 (1.7) | 101.9 (3.4) | 11.9 (0.9) | 0.16 | 20:37–20:37 | 108 (102–112) |
G5 | 232.1 (3.3) | 98–103 | 51.7 (2.2) | 103.3 (4.4) | 16.8 (1.3) | 0.00 | 18:00–18:00 | 102 (101–103) |
G6 | 243.9 (2.2) | 99–103 | 54.9 (0.9) | 109.9 (1.8) | 18.3 (0.8) | 0.75 | 9:00–9:00 | 109 (107–112) |
G7 | 219.9 (2.8) | 98–102 | 52.0 (2.0) | 104.0 (4.0) | 14.4 (0.7) | 0.20 | 8:53–8:53 | 104 (100–107) |