Fig. 3

Diminished capacity for VE after asbestos-exposure. MexTAg mice given access to VE either 2-weeks before (Pre-Exp VE), or 25-weeks after (Post-Exp VE) asbestos exposure displayed a significant and sustained decrease in both the amount of time spent running/night (a, c) and total distance travelled/night (b, d) over a 70 week period. This was in contrast to age-matched, non-asbestos exposed MexTAg controls (e–h), which maintained significantly higher VE capacity over a similar time period. (i-n) Changes in VE over time between respective asbestos exposed and age-matched, non-asbestos exposed control groups (i, j: Pre-Exp VE vs Young Ctrl; k, l: Post-Exp VE vs Old Ctrl and m, n Young vs. Old controls). Table depicts fold-change over time. Data shown is mean ± SD. (a–h) Data analysed using a non-parametric Kruskal–Wallis one way ANOVA with Dunn’s test for multiple comparisons to start of VE. (i–n) Data analysed via non-parametric, mixed model ANOVA. * = p<0.05, ** = p<0.01, *** = p<0.001, **** = p<0.0001